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HIV感染者腹痛的评估

Author
C Mel Wilcox, MD
Section Editor
John G Bartlett, MD
Deputy Editor
Jennifer Mitty, MD, MPH
Translators
李在村, 主任医师,副教授

引言

人类免疫缺陷病毒(human immunodeficiency virus, HIV)感染者腹痛的鉴别诊断可能包括严重免疫缺陷时的机会性感染[如,巨细胞病毒(cytomegalovirus, CMV)、鸟分枝杆菌复合体(mycobacterium avium complex, MAC)],也可能包括普通人群中较常见的一些其他病因(如,阑尾炎、憩室炎)。抗逆转录病毒治疗(antiretroviral therapy, ART)的广泛应用带来了很多药物副作用,包括胰腺炎和乳酸酸中毒综合征,这两者均可引起腹痛[1,2]。

本文将概述对HIV感染者腹痛的诊断。HIV感染者的其他胃肠道和肝胆并发症将单独讨论。 (参见“Evaluation of the HIV-infected patient with odynophagia and dysphagia”“HIV感染者腹泻的评估”“Evaluation of the HIV-infected patient with anorectal symptoms”“HIV感染者的肝胆疾病评估”)

发生率

胃肠道不适(包括腹痛)的发生率还不明确。在高效ART用于临床之前,严重腹痛见于约15%的HIV感染者,并且与生存率下降相关[3]。

基本原则

在评估艾滋病患者的胃肠道不适时,几个基本原则很有用:

单凭临床症状和体征很少能够明确诊断。

            

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Literature review current through: 2017-06 . | This topic last updated: 2015-08-18.
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References
Top
  1. Louie JK, Hsu LC, Osmond DH, et al. Trends in causes of death among persons with acquired immunodeficiency syndrome in the era of highly active antiretroviral therapy, San Francisco, 1994-1998. J Infect Dis 2002; 186:1023.
  2. Reisler RB, Murphy RL, Redfield RR, Parker RA. Incidence of pancreatitis in HIV-1-infected individuals enrolled in 20 adult AIDS clinical trials group studies: lessons learned. J Acquir Immune Defic Syndr 2005; 39:159.
  3. Parente F, Cernuschi M, Antinori S, et al. Severe abdominal pain in patients with AIDS: frequency, clinical aspects, causes, and outcome. Scand J Gastroenterol 1994; 29:511.
  4. Smit SJ, Du Toit RS. The acute AIDS abdomen--a prospective clinical and pathological study. S Afr J Surg 2005; 43:88.
  5. Sharma MP, Bhatia V. Abdominal tuberculosis. Indian J Med Res 2004; 120:305.
  6. Varsky CG, Correa MC, Sarmiento N, et al. Prevalence and etiology of gastroduodenal ulcer in HIV-positive patients: a comparative study of 497 symptomatic subjects evaluated by endoscopy. Am J Gastroenterol 1998; 93:935.
  7. Wood BJ, Kumar PN, Cooper C, et al. AIDS-associated intussusception in young adults. J Clin Gastroenterol 1995; 21:158.
  8. Cappell MS, Shetty V. A multicenter, case-controlled study of the clinical presentation and etiology of ascites and of the safety and clinical efficacy of diagnostic abdominal paracentesis in HIV seropositive patients. Am J Gastroenterol 1994; 89:2172.
  9. Wilcox CM, Forsmark CE, Darragh T, et al. High-protein ascites in patients with the acquired immunodeficiency syndrome. Gastroenterology 1991; 100:745.
  10. Cappell MS, Marks M. Acute pancreatitis in HIV-seropositive patients: a case control study of 44 patients. Am J Med 1995; 98:243.
  11. Bonacini M. Pancreatic involvement in human immunodeficiency virus infection. J Clin Gastroenterol 1991; 13:58.
  12. Wilcox CM, Forsmark CE, Grendell JH, et al. Cytomegalovirus-associated acute pancreatic disease in patients with acquired immunodeficiency syndrome. Report of two patients. Gastroenterology 1990; 99:263.
  13. Dassopoulos T, Ehrenpreis ED. Acute pancreatitis in human immunodeficiency virus-infected patients: a review. Am J Med 1999; 107:78.
  14. Pauwels A, Eliaszewicz M, Larrey D, et al. Pentamidine-induced acute pancreatitis in a patient with AIDS. J Clin Gastroenterol 1990; 12:457.
  15. Lai HY, Chen JH, Tsai PP, et al. Hepatic steatosis and pancreatitis associated with the use of stavudine in a patient with HIV infection. AJR Am J Roentgenol 2004; 183:1605.
  16. Perry RC, Cushing HE, Deeg MA, Prince MJ. Ritonavir, triglycerides, and pancreatitis. Clin Infect Dis 1999; 28:161.
  17. Wilmink T, Frick TW. Drug-induced pancreatitis. Drug Saf 1996; 14:406.
  18. Cooley TP, Kunches LM, Saunders CA, et al. Once-daily administration of 2',3'-dideoxyinosine (ddI) in patients with the acquired immunodeficiency syndrome or AIDS-related complex. Results of a Phase I trial. N Engl J Med 1990; 322:1340.
  19. Carrat F, Bani-Sadr F, Pol S, et al. Pegylated interferon alfa-2b vs standard interferon alfa-2b, plus ribavirin, for chronic hepatitis C in HIV-infected patients: a randomized controlled trial. JAMA 2004; 292:2839.
  20. Kirian MA, Higginson RT, Fulco PP. Acute onset of pancreatitis with concomitant use of tenofovir and didanosine. Ann Pharmacother 2004; 38:1660.
  21. Moreno A, Quereda C, Moreno L, et al. High rate of didanosine-related mitochondrial toxicity in HIV/HCV-coinfected patients receiving ribavirin. Antivir Ther 2004; 9:133.
  22. Moore RD, Keruly JC, Chaisson RE. Incidence of pancreatitis in HIV-infected patients receiving nucleoside reverse transcriptase inhibitor drugs. AIDS 2001; 15:617.
  23. Friedman SL, Wright TL, Altman DF. Gastrointestinal Kaposi's sarcoma in patients with acquired immunodeficiency syndrome. Endoscopic and autopsy findings. Gastroenterology 1985; 89:102.
  24. Greenberg RE, Bank S, Singer C. Macroamylasaemia in association with the acquired immunodeficiency syndrome. Postgrad Med J 1987; 63:677.
  25. Tonolini M, Bianco R. Acute HIV-related gastrointestinal disorders and complications in the antiretroviral era: spectrum of cross-sectional imaging findings. Abdom Imaging 2013; 38:994.
  26. Farman J, Lerner ME, Ng C, et al. Cytomegalovirus gastritis: protean radiologic features. Gastrointest Radiol 1992; 17:202.
  27. Rockey DC, Halvorsen RA Jr, Higgins JL, Cello JP. Prospective evaluation of patients with bowel wall thickening. Am J Gastroenterol 1995; 90:99.
  28. Ferguson CM. Surgical complications of human immunodeficiency virus infection. Am Surg 1988; 54:4.
  29. Saltzman DJ, Williams RA, Gelfand DV, Wilson SE. The surgeon and AIDS: twenty years later. Arch Surg 2005; 140:961.
  30. Sauerland S, Agresta F, Bergamaschi R, et al. Laparoscopy for abdominal emergencies: evidence-based guidelines of the European Association for Endoscopic Surgery. Surg Endosc 2006; 20:14.