成人容量不足的病因、临床表现和诊断
- Author
- Richard H Sterns, MD
Richard H Sterns, MD
- Editor-in-Chief — Nephrology
- Section Editor — Fluid and Electrolytes
- Professor Emeritus
- University of Rochester School of Medicine and Dentistry
- Section Editor
- Michael Emmett, MD
Michael Emmett, MD
- Editor-in-Chief — Nephrology
- Section Editor — Fluid and Electrolytes
- Chief of Internal Medicine
- Baylor University Medical Center
- Deputy Editor
- John P Forman, MD, MSc
John P Forman, MD, MSc
- Senior Deputy Editor — UpToDate
- Deputy Editor — Nephrology
- Assistant Professor of Medicine
- Harvard Medical School
- Translators
- 陈罡, 主治医师
陈罡, 主治医师
- 北京协和医院肾内科
引言
在多种临床疾病中,液体丢失降低细胞外液容量,可能损害组织灌注。早期诊断和积极治疗以恢复正常容量可挽救生命。
当含钠液体通过尿液、胃肠道或皮肤丢失或急性滞留于体内“第三间隙”,导致血管内容量减少,可能发生真正的容量不足。
当发生上述液体丢失时,2个因素起防止低血容量发生的作用:
●食物中的钠和水分摄入通常远高于基本需求。因此,除非摄入同时减少(如有厌食或呕吐),必须有大量液体丢失才会发生低血容量。
●肾脏通过增加钠和水分重吸收最大程度减少经尿液丢失。
Subscribers log in here
To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information or to purchase a personal subscription, click below on the option that best describes you:Literature review current through: 2017-06 . | This topic last updated: 2016-02-29.The content on the UpToDate website is not intended nor recommended as a substitute for medical advice, diagnosis, or treatment. Always seek the advice of your own physician or other qualified health care professional regarding any medical questions or conditions. The use of this website is governed by the UpToDate Terms of Use ©2017 UpToDate, Inc.References- Coleman AJ, Arias M, Carter NW, et al. The mechanism of salt wastage in chronic renal disease. J Clin Invest 1966; 45:1116.
- Danovitch GM, Bourgoignie J, Bricker NS. Reversibility of the "salt-losing" tendency of chronic renal failure. N Engl J Med 1977; 296:14.
- Better OS. Impaired fluid and electrolyte balance in hot climates. Kidney Int Suppl 1987; 21:S97.
- McGee S, Abernethy WB 3rd, Simel DL. The rational clinical examination. Is this patient hypovolemic? JAMA 1999; 281:1022.
- Weil MH, von Planta M, Rackow EC. Acute circulatory failure (shock). In: Heart Disease. A Textbook of Cardiovascular Medicine, Braunwald E (Ed), Saunders, Philadelphia 1988.
- Cohn JN. Blood pressure measurement in shock. Mechanism of inaccuracy in ausculatory and palpatory methods. JAMA 1967; 199:118.
- Vinayak AG, Levitt J, Gehlbach B, et al. Usefulness of the external jugular vein examination in detecting abnormal central venous pressure in critically ill patients. Arch Intern Med 2006; 166:2132.
- Dossetor JB. Creatininemia versus uremia. The relative significance of blood urea nitrogen and serum creatinine concentrations in azotemia. Ann Intern Med 1966; 65:1287.
- Baskett PJ. ABC of major trauma. Management of hypovolaemic shock. BMJ 1990; 300:1453.
- Sherman RA, Eisinger RP. The use (and misuse) of urinary sodium and chloride measurements. JAMA 1982; 247:3121.
- Miller TR, Anderson RJ, Linas SL, et al. Urinary diagnostic indices in acute renal failure: a prospective study. Ann Intern Med 1978; 89:47.
- Espinel CH, Gregory AW. Differential diagnosis of acute renal failure. Clin Nephrol 1980; 13:73.
- Rose BD. Pathophysiology of Renal Disease, 2d ed, McGraw-Hill, New York City 1987. p.82.
- LEVINSKY NG, DAVIDSON DG, BERLINER RW. Effects of reduced glomerular filtration on urine concentration in the presence of antidiuretic hormone. J Clin Invest 1959; 38:730.
- Marik PE, Baram M, Vahid B. Does central venous pressure predict fluid responsiveness? A systematic review of the literature and the tale of seven mares. Chest 2008; 134:172.
- DORHOUT MEES EJ. Relation between maximal urine concentration, maximal water reabsorption capacity, and mannitol clearance in patients with renal disease. Br Med J 1959; 1:1159.
- Meltzer JI, Keim HJ, Laragh JH, et al. Nephrotic syndrome: vasoconstriction and hypervolemic types indicated by renin-sodium profiling. Ann Intern Med 1979; 91:688.
- Schrier RW, Fassett RG. A critique of the overfill hypothesis of sodium and water retention in the nephrotic syndrome. Kidney Int 1998; 53:1111.
- Vande Walle JG, Donckerwolcke RA, van Isselt JW, et al. Volume regulation in children with early relapse of minimal-change nephrosis with or without hypovolaemic symptoms. Lancet 1995; 346:148.
- Vande Walle JG, Donckerwolcke RA, Koomans HA. Pathophysiology of edema formation in children with nephrotic syndrome not due to minimal change disease. J Am Soc Nephrol 1999; 10:323.
Topic Outline
Top