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成人慢性胰腺炎的病因和发病机制

Authors
Steven D Freedman, MD, PhD
Michele D Lewis, MD, MSSc
Section Editor
David C Whitcomb, MD, PhD
Deputy Editor
Shilpa Grover, MD, MPH, AGAF
Translators
钱家鸣, 主任医师，教授

引言

慢性胰腺炎是一种具有挑战性的疾病，通常表现为慢性顽固性疼痛且有发作性加重。尽管人们有时认为慢性胰腺炎会随时间推移“消失”，但即便有这种情况，要经历多长时间才会出现也是有很大差异的[1-4]。此外，随着疾病进展可能出现胰腺内分泌和外分泌功能失调，并可能出现各种并发症，包括假性囊肿、胆管或十二指肠梗阻、胰源性腹水、脾静脉血栓形成和假性动脉瘤。

慢性胰腺炎的病因和发病机制将总结在此。成人慢性胰腺炎的临床表现、诊断和治疗将单独讨论。 (参见“成人慢性胰腺炎的临床表现和诊断”和“慢性胰腺炎的治疗”)

定义

慢性胰腺炎是一种胰腺进行性纤维炎性病程，导致永久性结构损害，从而引起外分泌和内分泌功能受损[5]。

根据其基础形态可将慢性胰腺炎分为：伴或不伴钙化的大导管型和小导管型。

急性胰腺炎和慢性胰腺炎的区别

急性胰腺炎是对胰腺损伤的急性炎症反应，通常是非进展性的。急性胰腺炎反复发作则可能随时间推移导致慢性胰腺炎。慢性胰腺炎和急性胰腺炎可通过几个特征区分。

                

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Literature review current through: 2017-06 . | This topic last updated: 2016-07-18.
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