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嗜酸性粒细胞性胃肠炎

Authors
Calman Prussin, MD
Nirmala Gonsalves, MD
Section Editor
Lawrence S Friedman, MD
Deputy Editor
Shilpa Grover, MD, MPH, AGAF
Translators
林连捷, 副主任医师，副教授

引言

嗜酸性粒细胞性胃肠炎(eosinophilic gastroenteritis, EG)所属的一组疾病包括嗜酸细胞性食管炎、胃炎、肠炎和结肠炎，统称为“嗜酸性粒细胞性胃肠病”[1]。

本专题将总结EG的临床表现、诊断和治疗。嗜酸细胞性食管炎将单独详细讨论。 (参见“嗜酸细胞性食管炎的临床表现和诊断”)

定义

EG是一种炎症性疾病，其特征是嗜酸性粒细胞浸润胃和十二指肠，以及在一些病例中浸润食管和结肠且无任何已知的嗜酸性粒细胞增多的原因。

流行病学

有关EG患病率的数据有限；据估计，在美国EG的患病率是每100,000人中22-28例[2]。EG可累及任何年龄的患者，但通常存在于20-50岁，发病高峰是20-30岁[3-5]；报道称男性发病略占主导。

发病机制

尚未充分认识EG的发病机制，若干流行病学特征和临床特征提示有过敏性因素[3,6,7]。另外，EG患者的血清免疫球蛋白E(immunoglobulin E, IgE)水平升高[7-10]。 (参见下文‘临床表现’和‘实验室检查结果’)

                     

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Literature review current through: 2017-06 . | This topic last updated: 2017-03-02.
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