Medline ® Abstract for Reference 53
Management of occluded uncovered metallic stents in patients with malignant distal biliary obstructions using covered metallic stents.
Togawa O, Kawabe T, Isayama H, Nakai Y, Sasaki T, Arizumi T, Matsubara S, Ito Y, Yamamoto N, Sasahira N, Hirano K, Tsujino T, Toda N, Tada M, Yoshida H, Omata M
J Clin Gastroenterol. 2008;42(5):546.
BACKGROUND: Self-expandable metallic stents (EMSs) have been widely used for the palliative treatment of unresectable malignant biliary obstructions, but EMSs are often occluded owing to tumor ingrowth via the wire mesh. Currently, there is no consensus on the management of occluded EMSs. We evaluated the efficacy of a covered EMS as a second endoprosthesis in patients with an occluded EMS.
METHODS: Forty patients with an occluded uncovered EMS (14 men, 26 women; mean age 72 y, range 41 to 89 y) were studied. The patients suffered from the following: pancreatic cancer in 18, bile duct cancer in 11, gallbladder cancer in 5, lymph node metastasis in 4, and papillary cancer in 2. Of these, 26, 7, and 7 were treated with a covered EMS, an uncovered EMS, and a plastic stent (PS), respectively. The second stent was inserted as a stent-in-stent.
RESULTS: The mean patent period for the covered EMS was 220 days, whereas the mean patent periods for the uncovered EMS and plastic stent were 141and 58 days, respectively. The cumulative patency of the covered EMS group was significantly higher (P=0.0404) than that of the uncovered EMS group. No significant differences in survival were observed between the covered and uncovered groups. No serious complications occurred.
CONCLUSION: Insertion of a covered EMS is an effective and safe treatment for an occluded uncovered EMS.
Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.