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皮损的皮肤镜评估

Authors
Ashfaq A Marghoob, MD
Natalia Jaimes, MD
Section Editor
Hensin Tsao, MD, PhD
Deputy Editor
Rosamaria Corona, MD, DSc
Translators
刘洁, 副主任医师,副教授

引言

皮肤镜检查是一种无创性活体检查技术,主要用于色素性皮损的检查,但其也能帮助临床医生评估无色素性皮损。皮肤镜检查、皮表透光显微镜检查、入射光显微镜检查及皮表显微镜检查都是同义词。皮肤镜检查通过一种称为皮肤镜的手持式仪器来进行。该操作能够显示皮肤表面以下的结构,包括表皮层、表皮真皮交界处及真皮浅层,而这些结构靠肉眼无法观察到[1-3]。

皮肤镜诊断涉及到识别特异性结构的有无,从而排除或证实某诊断。从认知的角度上讲,这可以通过从细节到总体(bottom-up)或从总体到细节(top-down)的策略来完成。从细节到总体法是指观察者通过观察寻找突出的细节(个体特征)来获得诊断;而总体到细节策略是指观察者识别整体情况、假设可能的临床诊断,然后有目的地通过皮肤镜寻找特定表现以证实推测的临床诊断[4]。

本专题将总结几种主要运用从总体到细节策略的流程及评分系统,以帮助临床医生鉴别黑素细胞性皮损和非黑素细胞性皮损(第一步),并区分良性黑素细胞性皮损与可疑或恶性黑素细胞性皮损(第二步)。皮肤镜检查的一般原则,皮肤镜下结构术语,皮损的皮肤镜评估,以及面部、黏膜和肢端掌跖部皮损的皮肤镜评估将单独讨论。指(趾)甲色素沉着的皮肤镜检查以及皮肤癌分诊的皮肤镜检查流程也将单独讨论。

(参见“皮肤镜检查概述”)

(参见“皮肤镜检查在面部皮损中的应用”)

                     

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Literature review current through: 2017-06 . | This topic last updated: 2016-09-17.
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References
Top
  1. Marghoob AA, Swindle LD, Moricz CZ, et al. Instruments and new technologies for the in vivo diagnosis of melanoma. J Am Acad Dermatol 2003; 49:777.
  2. Menzies SW, Ingvar C, McCarthy WH. A sensitivity and specificity analysis of the surface microscopy features of invasive melanoma. Melanoma Res 1996; 6:55.
  3. Argenziano G, Soyer HP. Dermoscopy of pigmented skin lesions--a valuable tool for early diagnosis of melanoma. Lancet Oncol 2001; 2:443.
  4. Wolfe JM, Butcher SJ, Lee C, Hyle M. Changing your mind: on the contributions of top-down and bottom-up guidance in visual search for feature singletons. J Exp Psychol Hum Percept Perform 2003; 29:483.
  5. Argenziano G, Soyer HP, Chimenti S, et al. Dermoscopy of pigmented skin lesions: results of a consensus meeting via the Internet. J Am Acad Dermatol 2003; 48:679.
  6. Marghoob AA, Braun R. Proposal for a revised 2-step algorithm for the classification of lesions of the skin using dermoscopy. Arch Dermatol 2010; 146:426.
  7. Blum A, Clemens J, Argenziano G. Modified dermoscopic algorithm for the differentiation between melanocytic and nonmelanocytic skin tumors. J Cutan Med Surg 2006; 10:73.
  8. Stolz W, Riemann, A Cognetta AB, et al. ABCD rule of dermoscopy: a new practical method for early recognition of maligant melanoma. Eur J Dermatol 1994; 4:521.
  9. Pehamberger H, Steiner A, Wolff K. In vivo epiluminescence microscopy of pigmented skin lesions. I. Pattern analysis of pigmented skin lesions. J Am Acad Dermatol 1987; 17:571.
  10. Argenziano G, Fabbrocini G, Carli P, et al. Epiluminescence microscopy for the diagnosis of doubtful melanocytic skin lesions. Comparison of the ABCD rule of dermatoscopy and a new 7-point checklist based on pattern analysis. Arch Dermatol 1998; 134:1563.
  11. Henning JS, Dusza SW, Wang SQ, et al. The CASH (color, architecture, symmetry, and homogeneity) algorithm for dermoscopy. J Am Acad Dermatol 2007; 56:45.
  12. Soyer HP, Argenziano G, Zalaudek I, et al. Three-point checklist of dermoscopy. A new screening method for early detection of melanoma. Dermatology 2004; 208:27.
  13. Malvehy J, Puig S, Argenziano G, et al. Dermoscopy report: proposal for standardization. Results of a consensus meeting of the International Dermoscopy Society. J Am Acad Dermatol 2007; 57:84.
  14. Zaballos P, Puig S, Llambrich A, Malvehy J. Dermoscopy of dermatofibromas: a prospective morphological study of 412 cases. Arch Dermatol 2008; 144:75.
  15. Agero AL, Taliercio S, Dusza SW, et al. Conventional and polarized dermoscopy features of dermatofibroma. Arch Dermatol 2006; 142:1431.
  16. Menzies SW, Westerhoff K, Rabinovitz H, et al. Surface microscopy of pigmented basal cell carcinoma. Arch Dermatol 2000; 136:1012.
  17. Navarrete-Dechent C, Bajaj S, Marchetti MA, et al. Association of Shiny White Blotches and Strands With Nonpigmented Basal Cell Carcinoma: Evaluation of an Additional Dermoscopic Diagnostic Criterion. JAMA Dermatol 2016; 152:546.
  18. Zalaudek I, Giacomel J, Schmid K, et al. Dermatoscopy of facial actinic keratosis, intraepidermal carcinoma, and invasive squamous cell carcinoma: a progression model. J Am Acad Dermatol 2012; 66:589.
  19. Jaimes N, Zalaudek I, Braun RP, et al. Pearls of keratinizing tumors. Arch Dermatol 2012; 148:976.
  20. Rosendahl C, Cameron A, Argenziano G, et al. Dermoscopy of squamous cell carcinoma and keratoacanthoma. Arch Dermatol 2012; 148:1386.
  21. Braun RP, Rabinovitz HS, Krischer J, et al. Dermoscopy of pigmented seborrheic keratosis: a morphological study. Arch Dermatol 2002; 138:1556.
  22. Braun RP, Krischer J, Saurat JH. The "wobble sign" in epiluminescence microscopy as a novel clue to the differential diagnosis of pigmented skin lesions. Arch Dermatol 2000; 136:940.
  23. Johr RH. Pink lesions. Clin Dermatol 2002; 20:289.
  24. Zalaudek I, Kreusch J, Giacomel J, et al. How to diagnose nonpigmented skin tumors: a review of vascular structures seen with dermoscopy: part II. Nonmelanocytic skin tumors. J Am Acad Dermatol 2010; 63:377.
  25. Zalaudek I, Kreusch J, Giacomel J, et al. How to diagnose nonpigmented skin tumors: a review of vascular structures seen with dermoscopy: part I. Melanocytic skin tumors. J Am Acad Dermatol 2010; 63:361.
  26. Jaimes N, Braun RP, Thomas L, Marghoob AA. Clinical and dermoscopic characteristics of amelanotic melanomas that are not of the nodular subtype. J Eur Acad Dermatol Venereol 2012; 26:591.
  27. Carrera C, Marchetti MA, Dusza SW, et al. Validity and Reliability of Dermoscopic Criteria Used to Differentiate Nevi From Melanoma: A Web-Based International Dermoscopy Society Study. JAMA Dermatol 2016; 152:798.
  28. Kittler H, Pehamberger H, Wolff K, Binder M. Diagnostic accuracy of dermoscopy. Lancet Oncol 2002; 3:159.
  29. Zalaudek I, Argenziano G, Soyer HP, et al. Three-point checklist of dermoscopy: an open internet study. Br J Dermatol 2006; 154:431.
  30. Dolianitis C, Kelly J, Wolfe R, Simpson P. Comparative performance of 4 dermoscopic algorithms by nonexperts for the diagnosis of melanocytic lesions. Arch Dermatol 2005; 141:1008.
  31. Annessi G, Bono R, Sampogna F, et al. Sensitivity, specificity, and diagnostic accuracy of three dermoscopic algorithmic methods in the diagnosis of doubtful melanocytic lesions: the importance of light brown structureless areas in differentiating atypical melanocytic nevi from thin melanomas. J Am Acad Dermatol 2007; 56:759.
  32. Carli P, Quercioli E, Sestini S, et al. Pattern analysis, not simplified algorithms, is the most reliable method for teaching dermoscopy for melanoma diagnosis to residents in dermatology. Br J Dermatol 2003; 148:981.
  33. Pagnanelli G, Soyer HP, Argenziano G, et al. Diagnosis of pigmented skin lesions by dermoscopy: web-based training improves diagnostic performance of non-experts. Br J Dermatol 2003; 148:698.
  34. Haenssle HA, Korpas B, Hansen-Hagge C, et al. Seven-point checklist for dermatoscopy: performance during 10 years of prospective surveillance of patients at increased melanoma risk. J Am Acad Dermatol 2010; 62:785.
  35. Menzies SW, Ingvar C, Crotty KA, McCarthy WH. Frequency and morphologic characteristics of invasive melanomas lacking specific surface microscopic features. Arch Dermatol 1996; 132:1178.
  36. Menzies SW, Kreusch J, Byth K, et al. Dermoscopic evaluation of amelanotic and hypomelanotic melanoma. Arch Dermatol 2008; 144:1120.
  37. Argenziano G, Catricalà C, Ardigo M, et al. Seven-point checklist of dermoscopy revisited. Br J Dermatol 2011; 164:785.
  38. Argenziano G, Kittler H, Ferrara G, et al. Slow-growing melanoma: a dermoscopy follow-up study. Br J Dermatol 2010; 162:267.
  39. Henning JS, Stein JA, Yeung J, et al. CASH algorithm for dermoscopy revisited. Arch Dermatol 2008; 144:554.
  40. Rosendahl C, Cameron A, McColl I, Wilkinson D. Dermatoscopy in routine practice - 'chaos and clues'. Aust Fam Physician 2012; 41:482.
  41. Gachon J, Beaulieu P, Sei JF, et al. First prospective study of the recognition process of melanoma in dermatological practice. Arch Dermatol 2005; 141:434.
  42. Buhmann JM, Malik J, Perona P. Image recognition: visual grouping, recognition, and learning. Proc Natl Acad Sci U S A 1999; 96:14203.
  43. Marghoob AA, Korzenko AJ, Changchien L, et al. The beauty and the beast sign in dermoscopy. Dermatol Surg 2007; 33:1388.
  44. Hofmann-Wellenhof R, Blum A, Wolf IH, et al. Dermoscopic classification of atypical melanocytic nevi (Clark nevi). Arch Dermatol 2001; 137:1575.
  45. Binder M, Schwarz M, Winkler A, et al. Epiluminescence microscopy. A useful tool for the diagnosis of pigmented skin lesions for formally trained dermatologists. Arch Dermatol 1995; 131:286.
  46. Bystryn JC. Epiluminescence microscopy: a reevaluation of its purpose. Arch Dermatol 2001; 137:377.
  47. Suh KY, Bolognia JL. Signature nevi. J Am Acad Dermatol 2009; 60:508.
  48. Grob JJ, Bonerandi JJ. The 'ugly duckling' sign: identification of the common characteristics of nevi in an individual as a basis for melanoma screening. Arch Dermatol 1998; 134:103.
  49. Argenziano G, Catricalà C, Ardigo M, et al. Dermoscopy of patients with multiple nevi: Improved management recommendations using a comparative diagnostic approach. Arch Dermatol 2011; 147:46.
  50. Altamura D, Avramidis M, Menzies SW. Assessment of the optimal interval for and sensitivity of short-term sequential digital dermoscopy monitoring for the diagnosis of melanoma. Arch Dermatol 2008; 144:502.
  51. Liu W, Hill D, Gibbs AF, et al. What features do patients notice that help to distinguish between benign pigmented lesions and melanomas?: the ABCD(E) rule versus the seven-point checklist. Melanoma Res 2005; 15:549.
  52. Ng PC, Barzilai DA, Ismail SA, et al. Evaluating invasive cutaneous melanoma: is the initial biopsy representative of the final depth? J Am Acad Dermatol 2003; 48:420.
  53. Marsden JR, Newton-Bishop JA, Burrows L, et al. Revised UK guidelines for the management of cutaneous melanoma 2010. J Plast Reconstr Aesthet Surg 2010; 63:1401.
  54. http://www.aad.org/education/clinical-guidelines.
  55. Coit DG, Andtbacka R, Bichakjian CK, et al. Melanoma. J Natl Compr Canc Netw 2009; 7:250.
  56. Menzies SW, Gutenev A, Avramidis M, et al. Short-term digital surface microscopic monitoring of atypical or changing melanocytic lesions. Arch Dermatol 2001; 137:1583.
  57. Argenziano G, Mordente I, Ferrara G, et al. Dermoscopic monitoring of melanocytic skin lesions: clinical outcome and patient compliance vary according to follow-up protocols. Br J Dermatol 2008; 159:331.
  58. Fuller SR, Bowen GM, Tanner B, et al. Digital dermoscopic monitoring of atypical nevi in patients at risk for melanoma. Dermatol Surg 2007; 33:1198.
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