Medline ® Abstracts for References 99,100
Failure of high-dose tocopherol to prevent alopecia induced by doxorubicin.
Martin-Jimenez M, Diaz-Rubio E, Gonzalez Larriba JL, Sangro B
N Engl J Med. 1986;315(14):894.
High-dose alpha-tocopherol as a preventive of doxorubicin-induced alopecia.
Perez JE, Macchiavelli M, Leone BA, Romero A, Rabinovich MG, Goldar D, Vallejo C
Cancer Treat Rep. 1986;70(10):1213.
The effectiveness of alpha-tocopherol acetate as a preventive of doxorubicin-induced alopecia was evaluated in 20 patients with different types of solid tumors. All received therapy containing doxorubicin in a dose range of 50-60 mg/m2/cycle of treatment. The observed hair loss was severe in 90% and moderate in 10% of the patients. No protective activity of alpha-tocopherol was demonstrated in this trial.