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Medline ® Abstract for Reference 94

of '化疗引起的脱发'

94
TI
Protection from chemotherapy-induced alopecia by 1,25-dihydroxyvitamin D3.
AU
Jimenez JJ, Yunis AA
SO
Cancer Res. 1992;52(18):5123.
 
We have previously reported that several biological agents, when given simultaneously with cytosine arabinoside or cytoxan, will protect from cytosine arabinoside-induced but not from cytoxan-induced alopecia. In the present study we used the secosteroid 1,25-dihydroxyvitamin D3 in a different timing schedule to protect from chemotherapy-induced alopecia. In three separate experiments, 0.2 microgram of topical, 1,25-dihydroxyvitamin D3 protected rats from alopecia induced by etoposide, cytoxan, and an Adriamycin-cytoxan combination. In another experiment, 0.1 microgram protected rats from etoposide-induced alopecia at the site of application. 1,25-Dihydroxyvitamin D3 may offer a new and exciting approach to the prevention of chemotherapy-induced alopecia.
AD
Department of Medicine, University of Miami School of Medicine, Florida.
PMID