Medline ® Abstracts for References 92,93
Minoxidil (Mx) as a prophylaxis of doxorubicin--induced alopecia.
Rodriguez R, Machiavelli M, Leone B, Romero A, Cuevas MA, Langhi M, Romero Acuña L, Romero Acuña J, Amato S, Barbieri M
Ann Oncol. 1994;5(8):769.
BACKGROUND: Minoxidil (Mx) is known to induce hair growth in men with male-pattern baldness. Based on this potential, the effectiveness of Mx 2% topical solution was evaluated in cancer patients (pts) to prevent doxorubicin-induced alopecia.
PATIENTS AND METHODS: 48 female pts with different types of solid tumors treated with doxorubicin-based chemotherapy in a dose range of 50-60 mg/m2/cycle were randomly assigned to receive Mx 2% topical solution or placebo.
RESULTS: 88% and 92% of pts in both arms showed severe alopecia (p = ns). No adverse effects were observed.
CONCLUSION: In this study Mx 2% topical solution was non-toxic but was not effective in the prevention of chemotherapy-induced alopecia.
Grupo Oncológico Cooperativo del Sur (G.O.C.S.), Neuquén, República Argentina.
A randomized trial of minoxidil in chemotherapy-induced alopecia.
Duvic M, Lemak NA, Valero V, Hymes SR, Farmer KL, Hortobagyi GN, Trancik RJ, Bandstra BA, Compton LD
J Am Acad Dermatol. 1996;35(1):74.
BACKGROUND: Hair loss is a side effect of many chemotherapeutic agents, and patients have even refused possibly palliative or lifesaving drugs because they could not accept temporary or prolonged baldness. Topical minoxidil has been shown to be effective for androgenetic alopecia and alopecia areata.
OBJECTIVE: Our purpose was to investigate the value and safety of minoxidil in chemotherapy-induced hair loss.
METHODS: Twenty-two women who were facing adjuvant chemotherapy after breast surgery were registered in a protocol that used a 2% minoxidil topical solution or a placebo in a randomized double-blind trial.
RESULTS: There was a statistically significant difference (favoring minoxidil) in the interval from maximal hair loss to first regrowth. Thus the period of baldness was shortened (mean, 50.2 days) in the minoxidil group.
CONCLUSION: Minoxidil decreased the duration of alopecia caused by chemotherapy. There were no significant side effects.
Department of Medical Specialties, University of Texas, M. D. Anderson Cancer Center, Houston 77030, USA.