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Medline ® Abstract for Reference 5

of '肝病患者的化疗肝毒性和剂量调整'

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Veno-occlusive liver disease after dacarbazine therapy (DTIC) for melanoma.
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Erichsen C, Jönsson PE
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J Surg Oncol. 1984;27(4):268.
 
A case of veno-occlusive disease of the liver with fatal outcome after dacarbazine (DTIC) therapy for melanoma is reported. There was a fulminant clinical course from start of symptoms until death. At autopsy the liver was enlarged and firm with signs of venous congestion. Small- and medium-sized hepatic veins were blocked by thrombosis. Eosinophilic infiltrations were found around the vessels. Published cases from the literature are reviewed and pertinent features discussed.
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PMID