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Medline ® Abstract for Reference 167

of '肝病患者的化疗肝毒性和剂量调整'

167
TI
Taxanes: a new class of antitumor agents.
AU
Huizing MT, Misser VH, Pieters RC, ten Bokkel Huinink WW, Veenhof CH, Vermorken JB, Pinedo HM, Beijnen JH
SO
Cancer Invest. 1995;13(4):381.
 
Taxanes belong to a new group of antineoplastic agents with a novel mechanism of action for a cytotoxic drug. They promote microtubule assembly and stabilize the microtubules. Paclitaxel, the first agent in this group to become available, was isolated from the Pacific yew, Taxus brevifolia, in 1971. In preclinical and clinical studies, paclitaxel and its semisynthetic analog docetaxel exhibit significant antitumor activity. This review deals with the physicochemical properties, pharmacology, and results of preclinical and clinical trials of the taxanes.
AD
Department of Pharmacy, Slotervaart Hospital, Amsterdam, The Netherlands.
PMID