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Medline ® Abstract for Reference 158

of '肝病患者的化疗肝毒性和剂量调整'

158
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Phase II studies of dianhydrogalactitol and VP-16-213 in colorectal cancer.
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Perry MC, Moertel CG, Schutt AJ, Reitemeier RJ, Hahn RG
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Cancer Treat Rep. 1976;60(9):1247.
 
Phase II chemotherapy trials of dianhydrogalactitol and VP-16-213 were conducted in patients with metastatic colorectal cancer who had measurable malignant disease which served as indicators of response to therapy. Dianhydrogalactitol was given in a 5-day course at a dosage of 30 mg/m2/day. Toxic reactions included nausea, vomiting, leukopenia, thrombocytopenia, and anemia. There was a definite tendency to a compounding of hematologic toxicity with repeated courses. No evidence of objective therapeutic response was observed among 30 patients treated. VP-16-213 was given at a dosage of 130 mg/m2 on Days 1, 3, and 5. Toxic reactions included nausea, vomiting, alopecia, leukopenia, thrombocytopenia, and anemia. Hematologic toxicity was more severe in patients with elevated serum bilirubin levels. No evidence of objective therapeutic response was observed among 28 patients treated.
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PMID