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Medline ® Abstract for Reference 14

of '肝病患者的化疗肝毒性和剂量调整'

14
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Hepatic veno-occlusive disease caused by 6-thioguanine.
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Gill RA, Onstad GR, Cardamone JM, Maneval DC, Sumner HW
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Ann Intern Med. 1982;96(1):58.
 
Clinically reversible veno-occlusive disease of the liver developed in a 23-year-old man with acute lymphocytic leukemia after 10 months of maintenance therapy with 6-thioguanine. Serial liver biopsies showed the development and resolution of intense sinusoidal engorgement. Although this disease was clinically reversible, some subintimal fibrosis about the terminal hepatic veins persisted. This case presented a unique opportunity to observe the histologic features of clinically reversible hepatic veno-occlusive disease over time, and may be the first case of veno-occlusive related solely to 6-thioguanine.
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PMID