化学恐怖袭击的快速识别及初步医疗处置
- Author
- James M Madsen, MD, MPH, FCAP, FACOEM, COL, MC-FS, USA
James M Madsen, MD, MPH, FCAP, FACOEM, COL, MC-FS, USA
- US Army Medical Research Institute of Chemical Defense, APG-EA, MD
- Uniformed Services University of the Health Sciences, Bethesda, MD
- Section Editors
- Richard D Zane, MD
Richard D Zane, MD
- Section Editor — Emergency Medical Services/Disaster Medicine
- Professor and Chair of Emergency Medicine
- University of Colorado School of Medicine
- Stephen J Traub, MD
Stephen J Traub, MD
- Section Editor — Toxicology
- Associate Professor of Emergency Medicine
- Mayo Medical School
- Michele M Burns, MD, MPH
Michele M Burns, MD, MPH
- Section Editor — Pediatric Toxicology
- Assistant Professor of Pediatrics and Emergency Medicine
- Harvard Medical School
- Deputy Editor
- James F Wiley, II, MD, MPH
James F Wiley, II, MD, MPH
- Senior Deputy Editor — UpToDate
- Deputy Editor — Adult and Pediatric Emergency Medicine
- Deputy Editor — Primary Care Sports Medicine (Adolescents and Adults)
- Clinical Professor of Pediatrics and Emergency Medicine/Traumatology
- University of Connecticut School of Medicine
- Translators
- 刘继海, 副主任医师,副教授
刘继海, 副主任医师,副教授
- 北京协和医院急诊科
引言
恐怖组织可能发动涵盖化学、生物、放射、核及烈性炸药(chemical, biological, radiological, nuclear, and high explosive, CBRNE)的恐怖事件[1]。对于暴露于最可能用于战场或恐怖袭击的化学物质的患者,本文提供了快速识别接触和初步处置的指南。
生物恐怖袭击,以及辐射暴露(包括核恐怖袭击所致暴露)的临床特征及治疗见其他专题。 (参见“Identifying and managing casualties of biological terrorism”和“Clinical features of radiation exposure in children”和“成人辐射损伤的生物学和临床特征”和“Management of radiation exposure in children following a nuclear disaster”和“成人放射性损伤的治疗”)
本文不涉及大规模杀伤性武器的现场及医疗应对预案和准备,这方面的内容见其他专题[2-11]。
背景
化学武器的使用违反现行国际法,并且受到联合国条约的管辖。《禁止开发、生产、储存、使用化学武器及销毁此种武器的公约》或称《化学武器公约》(Chemical Weapons Convention, CWC)自1997年开始实施。该公约由荷兰海牙的国际禁止化学武器组织(Organisation for the Prohibition of Chemical Weapons, OPCW)执行[12]。
尽管国际公约禁止使用化学武器,但是多个国家仍大量储备有各类化学武器,其针对军队及平民的使用记录如下:
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- Couch D. United States Armed Forces Nuclear, Biological and Chemical Survival Manual, Basic Books, New York 2003.
- Henretig FM, Cieslak TJ, Eitzen EM Jr. Biological and chemical terrorism. J Pediatr 2002; 141:311.
- Acquista A. The Survival Guide: what to do in a biological, chemical or nuclear emergency, Random House, New York 2003.
- Greenfield RA, Brown BR, Hutchins JB, et al. Microbiological, biological, and chemical weapons of warfare and terrorism. Am J Med Sci 2002; 323:326.
- Furlow B. Biological, chemical and radiological terrorism. Radiol Technol 2003; 75:91.
- Heymann WR. Threats of biological and chemical warfare on civilian populations. J Am Acad Dermatol 2004; 51:452.
- Gosden C, Gardener D. Weapons of mass destruction--threats and responses. BMJ 2005; 331:397.
- Fry DE. Chemical threats. Surg Clin North Am 2006; 86:637.
- Prockop LD. Weapons of mass destruction: Overview of the CBRNEs (Chemical, Biological, Radiological, Nuclear, and Explosives). J Neurol Sci 2006; 249:50.
- Bland SA. Chemical, biological and radiation casualties: critical care considerations. J R Army Med Corps 2009; 155:160.
- Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons and on their Destruction (Chemical Weapons Convention). http://www.opcw.org/chemical-weapons-convention/ (Accessed on May 21, 2013).
- Vogel L. WHO releases guidelines for treating chemical warfare victims after possible Syria attacks. CMAJ 2013; 185:E665.
- Report on Allegations of the Use of Chemical Weapons in the Ghouta Area of Damascus on 21 August 2013. United Nations Mission to Investigate Allegations of the Use of Chemical Weapons in the Syrian Arab Republic. United Nations. http://www.un.org/disarmament/content/slideshow/Secretary_General_Report_of_CW_Investigation.pdf. (Accessed on October 01, 2013).
- Kadivar H, Adams SC. Treatment of chemical and biological warfare injuries: insights derived from the 1984 Iraqi attack on Majnoon Island. Mil Med 1991; 156:171.
- Hu H, Cook-Deegan R, Shukri A. The use of chemical weapons. Conducting an investigation using survey epidemiology. JAMA 1989; 262:640.
- Okumura T, Suzuki K, Fukuda A, et al. The Tokyo subway sarin attack: disaster management, Part 1: Community emergency response. Acad Emerg Med 1998; 5:613.
- Okumura T, Suzuki K, Fukuda A, et al. The Tokyo subway sarin attack: disaster management, Part 2: Hospital response. Acad Emerg Med 1998; 5:618.
- Jones R, Wills B, Kang C. Chlorine gas: an evolving hazardous material threat and unconventional weapon. West J Emerg Med 2010; 11:151.
- Tucker JB. The current bioweapons threat. In: Biopreparedness and Public Health, Hunger I, Radosavljevic V, Belojevic G Rotz LD. (Eds), Springer Netherlands, Amsterdam 2013. p.7.
- Anderson PD. Emergency management of chemical weapons injuries. J Pharm Pract 2012; 25:61.
- Kuca K, Pohanka M. Chemical warfare agents. EXS 2010; 100:543.
- Swaran JSF, Flora G, Saxena G. Arsenicals: Toxicity, their use as chemical warfare agents, and possible remedial measures. In: Handbook of Toxicology of Chemical Warfare Agents, Gupta RC. (Ed), Academic Press, 2009. p.109.
- Homeland Security Presidential Directive/HSPD-18. http://www.fas.org/irp/offdocs/nspd/hspd-18.html (Accessed on May 10, 2013).
- Burklow TR, Yu CE, Madsen JM. Industrial chemicals: terrorist weapons of opportunity. Pediatr Ann 2003; 32:230.
- Reedy SJ, Schwartz MD, Morgan BW. Suicide fads: frequency and characteristics of hydrogen sulfide suicides in the United States. West J Emerg Med 2011; 12:300.
- Madsen JM. Toxins as weapons of mass destruction. A comparison and contrast with biological-warfare and chemical-warfare agents. Clin Lab Med 2001; 21:593.
- Aas P. The threat of mid-spectrum chemical warfare agents. Prehosp Disaster Med 2003; 18:306.
- Wormser U. Toxicology of mustard gas. Trends Pharmacol Sci 1991; 12:164.
- Patel MM, Schier JG, Belson MG. Recognition of illness associated with covert chemical releases. Pediatr Emerg Care 2006; 22:592.
- Cieslak TJ, Rowe JR, Kortepeter MG, et al. A field-expedient algorithmic approach to the clinical management of chemical and biological casualties. Mil Med 2000; 165:659.
- Tuorinsky SD, Sciuto AM. Toxic inhalational injury and toxic industrial chemicals. In: Medical aspects of chemical warfare, 2nd ed, Tuorinsky SD (Ed), Office of the Surgeon General,TMM Publications, Washington, DC 2008. p.339.
- Hurst CG, Petrali JP, Barillo DJ, et al. Vesicants. In: Medical aspects of chemical warfare, 2nd ed, Tuorinsky SD (Ed), Office of the Surgeon General,TMM Publications, Washington, DC 2008. p.259.
- Busl KM, Bleck TP. Treatment of neuroterrorism. Neurotherapeutics 2012; 9:139.
- Rimpel LY, Boehm DE, O'Hern MR, et al. Chemical defense equipment. In: Medical Aspects of Chemical Warfare, 2nd ed, Tuorinsky SD (Ed), United States Department of the Army, Office of the Surgeon General at TMM Publications, Bordent Institute, Washington, DC 2008. p.559.
- Capacio BR, Smith JR, Gordon RK, et al. Medical diagnostics. In: Medical Aspects of Chemical Warfare, 2nd ed, Tuorinsky SD (Ed), Unites States, Department of the Army, Office of the Surgeon General, Borden Instittute, Washington, DC 2008. p.691.
- Chemical hazards emergency medical management. United States Department of Health and Human Services. www.chemm.nlm.nih.gov/onsite.htm (Accessed on August 06, 2013).
- General description and discussion of the levels of protection and protective gear. Occupational Safety and Health Standards: Hazardous Materials. Standard number: 1910.120 App B. www.osha.gov/pls/oshaweb/owadisp.show_document?p_table=STANDARDS&p_id=9767 (Accessed on August 07, 2013).
- Occupational Safety and Health Administration (OSHA). Best Practices for Protecting EMS Responders during Treatment and Transport of Victims of Hazardous Substance Releases. http://www.osha.gov/Publications/OSHA3370-protecting-EMS-respondersSM.pdf (Accessed on May 10, 2013).
- Occupational Safety and Health Administration (OSHA). OSHA Best Practices for Hospital-based First Receivers of Victims from Mass Casualty Incidents Involving the Release of Hazardous Substances. http://www.osha.gov/dts/osta/bestpractices/html/hospital_first receivers.html and http://www.osha.gov/dits/osta/bestpractices/firstreceivers_hospital.pdf (Accessed on May 10, 2013).
- McLaughlin S. Chemical reaction. A look at OSHA's guidance for chemical incident first receivers. Health Facil Manage 2005; 18:36, 38, 40.
- Cone DC, Koenig KL. Mass casualty triage in the chemical, biological, radiological, or nuclear environment. Eur J Emerg Med 2005; 12:287.
- Subbarao I, Johnson C, Bond WF, et al. Symptom-based, algorithmic approach for handling the initial encounter with victims of a potential terrorist attack. Prehosp Disaster Med 2005; 20:301.
- Triage guidelines. Chemical Hazards Medical Management. US Department of Health and Human Services. http://www.chemm.nlm.nih.gov/triage.htm#sec1 (Accessed on August 07, 2013).
- Brown JS Jr. Psychiatric issues in toxic exposures. Psychiatr Clin North Am 2007; 30:837.
- Lawrence DT, Kirk MA. Chemical terrorism attacks: update on antidotes. Emerg Med Clin North Am 2007; 25:567.
- Pettineo C, Aitchison R, Leikin SM, et al. Biological and chemical weapons of mass destruction: updated clinical therapeutic countermeasures since 2003. Am J Ther 2009; 16:35.
- Rodgers GC Jr, Condurache CT. Antidotes and treatments for chemical warfare/terrorism agents: an evidence-based review. Clin Pharmacol Ther 2010; 88:318.
- Braue EH, Boardman CH, Hurst CG. Decontamination of chemical casualties. In: Medical Aspects of Chemical Warfare, 2nd ed, Tuorinsky SD (Ed), United States Department of the Army, Office of the Surgeon General at TMM Publications, Borden Institute, Washington, DC, 2008, p. 527. https://ke.army.mil/bordeninstitute/published_volumes/chemwarfare/Chem-ch16_pg527-558.pdf (Accessed on August 27, 2013).
- Protopam® Injection Supplement S-024 DRAFT Package Insert. Food and Drug Administration, United States of America. http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/14134s24lbl.pdf (Accessed on September 20, 2010).
- Schwartz MD, Hurst CG, Kirk MA, et al. Reactive skin decontamination lotion (RSDL) for the decontamination of chemical warfare agent (CWA) dermal exposure. Curr Pharm Biotechnol 2012; 13:1971.
- Houston M, Hendrickson RG. Decontamination. Crit Care Clin 2005; 21:653.
- Byers M, Russell M, Lockey DJ. Clinical care in the "Hot Zone". Emerg Med J 2008; 25:108.
- Macintyre AG, Christopher GW, Eitzen E Jr, et al. Weapons of mass destruction events with contaminated casualties: effective planning for health care facilities. JAMA 2000; 283:242.
- Nerve agents - prehospital management. Chemical Hazards Emergency Medical Management. US Department of Health and Human Services. http://www.chemm.nlm.nih.gov/na_prehospital_mmg.htm#top (Accessed on September 07, 2013).
- Murray DB, Eddleston M, Thomas S, et al. Rapid and complete bioavailability of antidotes for organophosphorus nerve agent and cyanide poisoning in minipigs after intraosseous administration. Ann Emerg Med 2012; 60:424.
- HHS pursues nerve agent anti-seizure drug for children and adults. US Department of Health and Human Services. HHS.gov. http://www.hhs.gov/news/press/2013pres/09/20130925b.html (Accessed on October 07, 2013).
- Gourley, SR. US Marine Corps Chemical Biological Incident Response Force. Military Medical Technology 2003; 7:6.
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