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Medline ® Abstract for Reference 49

of '慢性髓系白血病的细胞和分子生物学'

49
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Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene.
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Tybulewicz VL, Crawford CE, Jackson PK, Bronson RT, Mulligan RC
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Cell. 1991;65(7):1153.
 
The c-abl proto-oncogene, which encodes a cytoplasmic protein-tyrosine kinase, is expressed throughout murine gestation and ubiquitously in adult mouse tissues. However, its levels are highest in thymus, spleen, and testes. To examine the in vivo role of c-abl, the gene was disrupted in embryonic stem cells, and the resulting genetically modified cells were used to establish a mouse strain carrying the mutation. Most mice homozygous for the c-abl mutation became runted and died 1 to 2 weeks after birth. In addition, many showed thymic and splenic atrophy and a T and B cell lymphopenia.
AD
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142.
PMID