UpToDate
Official reprint from UpToDate®
www.uptodate.com ©2017 UpToDate®

儿童急性阑尾炎:临床表现与诊断

Author
David E Wesson, MD
Section Editor
Jonathan I Singer, MD
Deputy Editor
James F Wiley, II, MD, MPH
Translators
陈杰, 副主任医师

引言

阑尾炎是儿童急诊腹部手术中最常见的疾病。获得成功结局的关键是在阑尾发生坏疽或穿孔前早期诊断和及时行阑尾切除术。

相比于较年幼儿童,大龄儿童及青少年更常发生阑尾炎,并且其临床特征往往与成人阑尾炎相似。而对于较年幼的儿童,因为其临床表现可能为非特异性的、症状不能充分表现出来,以及患儿往往焦虑不安与不适,使得很难进行评估,所以阑尾炎的诊断特别困难。在进行阑尾炎评估的特定儿童中,实验室检测和影像学检查是有用的辅助手段,影像学检查主要为超声(ultrasound, US)和计算机断层扫描(computed tomography, CT)或磁共振成像(magnetic resonance imaging, MRI)。

本专题将讨论儿童急性阑尾炎的流行病学、临床特征,以及对疑似阑尾炎儿童的评估。关于儿童阑尾炎诊断性影像学检查和治疗的详细讨论参见其他专题。 (参见“儿童急性阑尾炎:诊断成像”“儿童急性阑尾炎的处理”)

解剖学

阑尾起自盲肠,大多数儿童的阑尾位于右下腹(right lower quadrant, RLQ)。在先天性肠道位置异常(如,未经矫正的肠旋转不良)、全内脏反位的儿童中,以及膈疝、腹裂和脐膨出修复术后,阑尾可以位于上腹部或腹腔左侧[1]。

阑尾的一些解剖学特点可能在整个儿童期阑尾炎的发生率及表现方面有一定作用。这些包括以下方面[2]:

                           

Subscribers log in here

To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information or to purchase a personal subscription, click below on the option that best describes you:
Literature review current through: 2017-06 . | This topic last updated: 2017-05-03.
The content on the UpToDate website is not intended nor recommended as a substitute for medical advice, diagnosis, or treatment. Always seek the advice of your own physician or other qualified health care professional regarding any medical questions or conditions. The use of this website is governed by the UpToDate Terms of Use ©2017 UpToDate, Inc.
References
Top
  1. Akbulut S, Ulku A, Senol A, et al. Left-sided appendicitis: review of 95 published cases and a case report. World J Gastroenterol 2010; 16:5598.
  2. Bundy DG, Byerley JS, Liles EA, et al. Does this child have appendicitis? JAMA 2007; 298:438.
  3. Rabah R. Pathology of the appendix in children: an institutional experience and review of the literature. Pediatr Radiol 2007; 37:15.
  4. Bennion RS, Baron EJ, Thompson JE Jr, et al. The bacteriology of gangrenous and perforated appendicitis--revisited. Ann Surg 1990; 211:165.
  5. Lamps LW. Infectious causes of appendicitis. Infect Dis Clin North Am 2010; 24:995.
  6. Montgomery EA, Popek EJ. Intussusception, adenovirus, and children: a brief reaffirmation. Hum Pathol 1994; 25:169.
  7. Paik SY, Oh JT, Choi YJ, et al. Measles-related appendicitis. Arch Pathol Lab Med 2002; 126:82.
  8. Lopez-Navidad A, Domingo P, Cadafalch J, et al. Acute appendicitis complicating infectious mononucleosis: case report and review. Rev Infect Dis 1990; 12:297.
  9. Schmidt P, Koltai JL, Weltzien A. Actinomycosis of the appendix in childhood. Pediatr Surg Int 1999; 15:63.
  10. Arca MJ, Gates RL, Groner JI, et al. Clinical manifestations of appendiceal pinworms in children: an institutional experience and a review of the literature. Pediatr Surg Int 2004; 20:372.
  11. Sinha SN, Sinha BN. Appendicular perforation due to Ascaris lumbricoides. J Indian Med Assoc 1974; 63:396.
  12. Bass JA, Goldman J, Jackson MA, et al. Pediatric Crohn disease presenting as appendicitis: differentiating features from typical appendicitis. Eur J Pediatr Surg 2012; 22:274.
  13. Scott A, Upadhyay V. Carcinoid tumours of the appendix in children in Auckland, New Zealand: 1965-2008. N Z Med J 2011; 124:56.
  14. Sin IC, Ling ET, Prentice RS. Burkitt's lymphoma of the appendix: report of two cases. Hum Pathol 1980; 11:465.
  15. Chew DK, Borromeo JR, Gabriel YA, Holgersen LO. Duplication of the vermiform appendix. J Pediatr Surg 2000; 35:617.
  16. Scholer SJ, Pituch K, Orr DP, Dittus RS. Clinical outcomes of children with acute abdominal pain. Pediatrics 1996; 98:680.
  17. Reynolds SL, Jaffe DM. Diagnosing abdominal pain in a pediatric emergency department. Pediatr Emerg Care 1992; 8:126.
  18. Addiss DG, Shaffer N, Fowler BS, Tauxe RV. The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol 1990; 132:910.
  19. Ohmann C, Franke C, Kraemer M, Yang Q. [Status report on epidemiology of acute appendicitis]. Chirurg 2002; 73:769.
  20. Anderson JE, Bickler SW, Chang DC, Talamini MA. Examining a common disease with unknown etiology: trends in epidemiology and surgical management of appendicitis in California, 1995-2009. World J Surg 2012; 36:2787.
  21. Graham JM, Pokorny WJ, Harberg FJ. Acute appendicitis in preschool age children. Am J Surg 1980; 139:247.
  22. Rothrock SG, Pagane J. Acute appendicitis in children: emergency department diagnosis and management. Ann Emerg Med 2000; 36:39.
  23. Rothrock SG, Skeoch G, Rush JJ, Johnson NE. Clinical features of misdiagnosed appendicitis in children. Ann Emerg Med 1991; 20:45.
  24. Schwartz KL, Gilad E, Sigalet D, et al. Neonatal acute appendicitis: a proposed algorithm for timely diagnosis. J Pediatr Surg 2011; 46:2060.
  25. Horwitz JR, Gursoy M, Jaksic T, Lally KP. Importance of diarrhea as a presenting symptom of appendicitis in very young children. Am J Surg 1997; 173:80.
  26. Nance ML, Adamson WT, Hedrick HL. Appendicitis in the young child: a continuing diagnostic challenge. Pediatr Emerg Care 2000; 16:160.
  27. Colvin JM, Bachur R, Kharbanda A. The presentation of appendicitis in preadolescent children. Pediatr Emerg Care 2007; 23:849.
  28. Sakellaris G, Tilemis S, Charissis G. Acute appendicitis in preschool-age children. Eur J Pediatr 2005; 164:80.
  29. Lee SL, Stark R, Yaghoubian A, et al. Does age affect the outcomes and management of pediatric appendicitis? J Pediatr Surg 2011; 46:2342.
  30. Bonadio W, Peloquin P, Brazg J, et al. Appendicitis in preschool aged children: Regression analysis of factors associated with perforation outcome. J Pediatr Surg 2015; 50:1569.
  31. Bratton SL, Haberkern CM, Waldhausen JH. Acute appendicitis risks of complications: age and Medicaid insurance. Pediatrics 2000; 106:75.
  32. Bachur RG, Hennelly K, Callahan MJ, et al. Diagnostic imaging and negative appendectomy rates in children: effects of age and gender. Pediatrics 2012; 129:877.
  33. Wagner JM, McKinney WP, Carpenter JL. Does this patient have appendicitis? JAMA 1996; 276:1589.
  34. Becker T, Kharbanda A, Bachur R. Atypical clinical features of pediatric appendicitis. Acad Emerg Med 2007; 14:124.
  35. Schorlemmer GR, Herbst CA Jr. Perforated neonatal appendicitis. South Med J 1983; 76:536.
  36. Karaman A, Cavuşoğlu YH, Karaman I, Cakmak O. Seven cases of neonatal appendicitis with a review of the English language literature of the last century. Pediatr Surg Int 2003; 19:707.
  37. Kwok MY, Kim MK, Gorelick MH. Evidence-based approach to the diagnosis of appendicitis in children. Pediatr Emerg Care 2004; 20:690.
  38. Green R, Bulloch B, Kabani A, et al. Early analgesia for children with acute abdominal pain. Pediatrics 2005; 116:978.
  39. Bailey B, Bergeron S, Gravel J, et al. Efficacy and impact of intravenous morphine before surgical consultation in children with right lower quadrant pain suggestive of appendicitis: a randomized controlled trial. Ann Emerg Med 2007; 50:371.
  40. Anderson M, Collins E. Analgesia for children with acute abdominal pain and diagnostic accuracy. Arch Dis Child 2008; 93:995.
  41. Kessler C, Bauer SJ. Utility of the digital rectal examination in the emergency department: a review. J Emerg Med 2012; 43:1196.
  42. Dunning PG, Goldman MD. The incidence and value of rectal examination in children with suspected appendicitis. Ann R Coll Surg Engl 1991; 73:233.
  43. Blab E, Kohlhuber U, Tillawi S, et al. Advancements in the diagnosis of acute appendicitis in children and adolescents. Eur J Pediatr Surg 2004; 14:404.
  44. Martin AE, Vollman D, Adler B, Caniano DA. CT scans may not reduce the negative appendectomy rate in children. J Pediatr Surg 2004; 39:886.
  45. Partrick DA, Janik JE, Janik JS, et al. Increased CT scan utilization does not improve the diagnostic accuracy of appendicitis in children. J Pediatr Surg 2003; 38:659.
  46. Kosloske AM, Love CL, Rohrer JE, et al. The diagnosis of appendicitis in children: outcomes of a strategy based on pediatric surgical evaluation. Pediatrics 2004; 113:29.
  47. Goldman RD, Carter S, Stephens D, et al. Prospective validation of the pediatric appendicitis score. J Pediatr 2008; 153:278.
  48. Hatcher-Ross K. Sensitivity and specificity of the Pediatric Appendicitis Score. J Pediatr 2009; 154:308.
  49. Bhatt M, Joseph L, Ducharme FM, et al. Prospective validation of the pediatric appendicitis score in a Canadian pediatric emergency department. Acad Emerg Med 2009; 16:591.
  50. Kharbanda AB, Dudley NC, Bajaj L, et al. Validation and refinement of a prediction rule to identify children at low risk for acute appendicitis. Arch Pediatr Adolesc Med 2012; 166:738.
  51. Sack U, Biereder B, Elouahidi T, et al. Diagnostic value of blood inflammatory markers for detection of acute appendicitis in children. BMC Surg 2006; 6:15.
  52. Williams R, Mackway-Jones K. Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. White cell count and diagnosing appendicitis in children. Emerg Med J 2002; 19:428.
  53. Kharbanda AB, Cosme Y, Liu K, et al. Discriminative accuracy of novel and traditional biomarkers in children with suspected appendicitis adjusted for duration of abdominal pain. Acad Emerg Med 2011; 18:567.
  54. Wang LT, Prentiss KA, Simon JZ, et al. The use of white blood cell count and left shift in the diagnosis of appendicitis in children. Pediatr Emerg Care 2007; 23:69.
  55. Bates MF, Khander A, Steigman SA, et al. Use of white blood cell count and negative appendectomy rate. Pediatrics 2014; 133:e39.
  56. Peltola H, Ahlqvist J, Rapola J, et al. C-reactive protein compared with white blood cell count and erythrocyte sedimentation rate in the diagnosis of acute appendicitis in children. Acta Chir Scand 1986; 152:55.
  57. Chung JL, Kong MS, Lin SL, et al. Diagnostic value of C-reactive protein in children with perforated appendicitis. Eur J Pediatr 1996; 155:529.
  58. Kwan KY, Nager AL. Diagnosing pediatric appendicitis: usefulness of laboratory markers. Am J Emerg Med 2010; 28:1009.
  59. Gavela T, Cabeza B, Serrano A, Casado-Flores J. C-reactive protein and procalcitonin are predictors of the severity of acute appendicitis in children. Pediatr Emerg Care 2012; 28:416.
  60. Paajanen H, Somppi E. Early childhood appendicitis is still a difficult diagnosis. Acta Paediatr 1996; 85:459.
  61. Heitz C, Singer JI. Recurrent abdominal pain and hematuria. Pediatr Emerg Care 2011; 27:663.
  62. England RJ, Crabbe DC. Delayed diagnosis of appendicitis in children treated with antibiotics. Pediatr Surg Int 2006; 22:541.
  63. Samuel M. Pediatric appendicitis score. J Pediatr Surg 2002; 37:877.
  64. Kharbanda AB, Taylor GA, Fishman SJ, Bachur RG. A clinical decision rule to identify children at low risk for appendicitis. Pediatrics 2005; 116:709.
  65. Alvarado A. A practical score for the early diagnosis of acute appendicitis. Ann Emerg Med 1986; 15:557.
  66. Pogorelić Z, Rak S, Mrklić I, Jurić I. Prospective validation of Alvarado score and Pediatric Appendicitis Score for the diagnosis of acute appendicitis in children. Pediatr Emerg Care 2015; 31:164.
  67. Kharbanda AB, Stevenson MD, Macias CG, et al. Interrater reliability of clinical findings in children with possible appendicitis. Pediatrics 2012; 129:695.
  68. Ebell MH, Shinholser J. What are the most clinically useful cutoffs for the Alvarado and Pediatric Appendicitis Scores? A systematic review. Ann Emerg Med 2014; 64:365.
  69. Kharbanda AB. Appendicitis: do clinical scores matter? Ann Emerg Med 2014; 64:373.
  70. Zúñiga RV, Arribas JL, Montes SP, et al. Application of Pediatric Appendicitis Score on the emergency department of a secondary level hospital. Pediatr Emerg Care 2012; 28:489.
  71. Saucier A, Huang EY, Emeremni CA, Pershad J. Prospective evaluation of a clinical pathway for suspected appendicitis. Pediatrics 2014; 133:e88.
  72. Ohle R, O'Reilly F, O'Brien KK, et al. The Alvarado score for predicting acute appendicitis: a systematic review. BMC Med 2011; 9:139.
  73. Vázquez BJ, Thomas R, Pfluke J, et al. Clinical presentation and treatment considerations in children with acute omental torsion: a retrospective review. Am Surg 2010; 76:385.
  74. Mavridis G, Livaditi E, Baltogiannis N, et al. Primary omental torsion in children: ten-year experience. Pediatr Surg Int 2007; 23:879.
  75. Dann PH, Amodio JB, Rivera R, Fefferman NR. Primary bacterial peritonitis in otherwise healthy children: imaging findings. Pediatr Radiol 2005; 35:198.
  76. Antal P, Gauderer M, Koshy M, Berman B. Is the incidence of appendicitis reduced in patients with sickle cell disease? Pediatrics 1998; 101:E7.
  77. Al-Nazer MA, Al-Saeed HH, Al-Salem AH. Acute appendicitis in patients with sickle cell disease. Saudi Med J 2003; 24:974.
  78. Pezone I, Iezzi ML, Leone S. Retrocardiac pneumonia mimicking acute abdomen: a diagnostic challenge. Pediatr Emerg Care 2012; 28:1230.
  79. Hernandez JA, Swischuk LE, Angel CA, et al. Imaging of acute appendicitis: US as the primary imaging modality. Pediatr Radiol 2005; 35:392.
  80. Schulte B, Beyer D, Kaiser C, et al. Ultrasonography in suspected acute appendicitis in childhood-report of 1285 cases. Eur J Ultrasound 1998; 8:177.