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Vulvar intraepithelial neoplasia

Christine H Holschneider, MD
Section Editors
Barbara Goff, MD
Rochelle L Garcia, MD
Deputy Editor
Sandy J Falk, MD, FACOG


Vulvar intraepithelial neoplasia (VIN) is a premalignant condition of the vulva [1]. VIN refers to squamous lesions, which comprise the great majority of vulvar neoplasia. There is no routine screening for VIN or vulvar carcinoma.

The terminology, diagnosis, and treatment of VIN are reviewed here. The diagnosis and treatment of vulvar cancer are discussed separately. (See "Vulvar cancer: Clinical manifestations, diagnosis, and pathology" and "Squamous cell carcinoma of the vulva: Staging and surgical treatment".)


In 2004, the Vulvar Oncology Subcommittee of the International Society for the Study of Vulvar Diseases (ISSVD) published a classification system for vulvar intraepithelial neoplasia (VIN) [2]. This topic review will utilize the 2004 ISSVD nomenclature.

In 2004, VIN was classified into two main categories [2]:

VIN, usual type – Lesions associated with human papillomavirus (HPV). This category includes the former subclassifications of VIN: VIN, warty type; VIN, basaloid type; and VIN, mixed (warty, basaloid) type.


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Literature review current through: Sep 2016. | This topic last updated: Nov 7, 2014.
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