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Vulvar intraepithelial neoplasia

Christine H Holschneider, MD
Section Editors
Barbara Goff, MD
Rochelle L Garcia, MD
Deputy Editor
Sandy J Falk, MD, FACOG


Vulvar intraepithelial neoplasia (VIN) is a premalignant condition of the vulva [1]. VIN refers to squamous lesions, which comprise the great majority of vulvar neoplasia. There is no routine screening for VIN or vulvar carcinoma.

The terminology, diagnosis, and treatment of VIN are reviewed here. The diagnosis and treatment of vulvar cancer are discussed separately. (See "Vulvar cancer: Epidemiology, diagnosis, histopathology, and treatment of rare histologies" and "Squamous cell carcinoma of the vulva: Staging and surgical treatment".)


In 2015, International Society for the Study of Vulvovaginal Disease (ISSVD) published a classification system for vulvar intraepithelial neoplasia (VIN) [2]. This topic review will utilize the 2015 ISSVD nomenclature, except when citing studies that used a different terminology system. The World Health Organization (WHO) also issues terminology for vulvar neoplasia [3].

The 2015 ISVVD terminology for vulvar intraepithelial lesions is based on a review of previous ISSVD, Lower Anogenital Squamous Terminology (LAST), and WHO terminology, and addressing of the concerns about the LAST terminology [2]. The ISVVD terminology is:

Low-grade squamous intraepithelial lesion (LSIL) of the vulva (synonyms include vulvar LSIL, flat condyloma, or human papillomavirus [HPV] effect)

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Literature review current through: Nov 2017. | This topic last updated: Mar 17, 2017.
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