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Medline ® Abstract for Reference 67

of 'Vitamin D deficiency in adults: Definition, clinical manifestations, and treatment'

Vitamin D during pregnancy and infancy and infant serum 25-hydroxyvitamin D concentration.
Grant CC, Stewart AW, Scragg R, Milne T, Rowden J, Ekeroma A, Wall C, Mitchell EA, Crengle S, Trenholme A, Crane J, Camargo CA Jr
Pediatrics. 2014;133(1):e143. Epub 2013 Dec 16.
OBJECTIVE: To determine the vitamin D dose necessary to achieve serum 25-hydroxyvitamin D (25(OH)D) concentration≥20 ng/mL during infancy.
METHODS: A randomized, double-blind, placebo-controlled trial in New Zealand. Pregnant mothers, from 27 weeks' gestation to birth, and then their infants, from birth to age 6 months, were randomly assigned to 1 of 3 mother/infant groups: placebo/placebo, vitamin D3 1000/400 IU, or vitamin D3 2000/800 IU. Serum 25(OH)D and calcium concentrations were measured at enrollment, 36 weeks' gestation, in cord blood, and in infants at 2, 4, and 6 months of age.
RESULTS: Two-hundred-and-sixty pregnant women were randomized. At enrollment, the proportions with serum 25(OH)D≥20 ng/mL for placebo, lower-dose, and higher-dose groups were 54%, 64%, and 55%, respectively. The proportion with 25(OH)D≥20 ng/mL was larger in both intervention groups at 36 weeks' gestation (50%, 91%, 89%,P<.001). In comparison with placebo, the proportion of infants with 25(OH)D≥20 ng/mL was larger in both intervention groups to age 4 months: cord blood (22%, 72%, 71%, P<.001), 2 months (50%, 82%, 92%, P<.001), and 4 months (66%, 87%, 87%, P = .004), but only in the higher-dose group at age 6 months (74%, 82%, 89%, P = .07; higher dose versus placebo P = .03, lower dose versus placebo P = .21).
CONCLUSIONS: Daily vitamin D supplementation during pregnancy and then infancy with 1000/400 IU or 2000/800 IU increases the proportion of infants with 25(OH)D≥20 ng/mL, with the higher dose sustaining this increase for longer.
MBChB, Department of Paediatrics: Child and Youth Health, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Wellesley St, Auckland 1142, New Zealand. cc.grant@auckland.ac.nz.