Urinary tract infection in renal transplant recipients
- Carlos AQ Santos, MD, MPHS
Carlos AQ Santos, MD, MPHS
- Assistant Professor of Medicine
- Rush University Medical Center
- Daniel C Brennan, MD, FACP
Daniel C Brennan, MD, FACP
- Editor-in-Chief — Nephrology
- Section Editor — Renal Transplantation
- Professor of Medicine
- Medical Director and Co-Director of the Comprehensive Transplant Center, Department of Internal Medicine, Division of Nephrology
- Johns Hopkins Medical School
- Section Editors
- Barbara Murphy, MB, BAO, BCh, FRCPI
Barbara Murphy, MB, BAO, BCh, FRCPI
- Section Editor — Renal Transplantation
- Professor of Medicine
- Mount Sinai School of Medicine
- Kieren A Marr, MD
Kieren A Marr, MD
- Section Editor — Compromised Host Infections; Fungal Infections
- Professor of Medicine and Oncology
- Johns Hopkins University School of Medicine
Urinary tract infection (UTI) is the most common infection after kidney transplantation [1-4]. UTI is associated with the development of acute cellular rejection, impaired allograft function, allograft loss, and death [2,4-7]. Morbidity and mortality from UTI can be caused by recurrent and/or severe sepsis.
This topic reviews the definitions, epidemiology, microbiology, clinical manifestations, diagnosis, treatment, and prevention of bacterial UTI in kidney transplant recipients. UTI in the general population and among end-stage renal disease (ESRD) patients is discussed elsewhere. (See "Acute uncomplicated cystitis and pyelonephritis in women" and "Approach to the adult with asymptomatic bacteriuria" and "Recurrent urinary tract infection in women" and "Non-access-related infections in chronic dialysis patients", section on 'Genitourinary infection'.)
We use the following definitions when discussing asymptomatic bacteriuria and UTI in renal transplant recipients [3,4,7]:
●Asymptomatic bacteriuria in the transplant population is defined by the presence of >105 bacterial colony forming units per milliliter (CFU/mL) of urine on urine culture with no local or systemic symptoms of UTI.
●Uncomplicated UTI is the presence of >105 CFU/mL on urine culture with local urinary symptoms, such as dysuria, frequency, or urgency, but no systemic symptoms, such as fever or allograft pain.To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
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