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Unipolar major depression during pregnancy: Epidemiology, clinical features, assessment, and diagnosis

Sophie Grigoriadis, MD, MA, PhD, FRCPC
Section Editors
Peter P Roy-Byrne, MD
Charles J Lockwood, MD, MHCM
Deputy Editor
David Solomon, MD


Although pregnancy is usually a time of emotional well-being for women, many pregnant women suffer mental disorders, including new onset or recurrence of unipolar major depression [1]. Antenatal depression is often not recognized [2,3]; thus, screening is encouraged to facilitate diagnosis and treatment.  

This topic reviews the epidemiology, pathogenesis, clinical features, assessment, and diagnosis of depression during pregnancy. The association of antenatal depression with adverse pregnancy outcomes and adverse outcomes in the offspring is discussed separately, as is the treatment of antenatal depression, and the risks of prenatal antidepressants:

(See "Antenatal depression: Pregnancy and neonatal outcomes".)

(See "Antenatal depression: Risks of abnormal infant and child development".)

(See "Antenatal depression: Risks of cognitive impairment and psychopathology in the offspring".)


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Literature review current through: Sep 2016. | This topic last updated: Jul 14, 2016.
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