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Unipolar depression in adults: Epidemiology, pathogenesis, and neurobiology

INTRODUCTION

Depression is a major public health problem associated with increased functional disability and mortality. The annual economic consequences of depression were estimated at 83 billion dollars in the United States in 2000 [1] and 118 billion euro in Europe in 2004 [2].

The epidemiology, pathogenesis, and neurobiology of depression in adults are reviewed here. The clinical features, diagnosis, treatment, and prognosis of depression are discussed separately.

(See "Unipolar depression in adults: Assessment and diagnosis".)

(See "Unipolar major depression in adults: Choosing initial treatment".)

(See "Unipolar depression in adults: Treatment of resistant depression".)

                        

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Literature review current through: Aug 2014. | This topic last updated: Aug 13, 2014.
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