Renal disease is a common problem in multiple myeloma. The pathology is heterogeneous and may involve a variety of different mechanisms [1-7]. The frequency with which this occurs varies with the definition used for renal insufficiency.
A discussion of the types and causes of renal disease is the topic of this review. The pathogenesis and diagnosis of specific associated renal diseases and the treatment of renal disease in multiple myeloma are discussed separately. (See "Pathogenesis of immunoglobulin light chain (AL) amyloidosis and light and heavy chain deposition diseases" and "Pathogenesis and diagnosis of myeloma cast nephropathy (myeloma kidney)" and "Treatment of kidney disease in multiple myeloma".)
TYPES OF RENAL DISEASE
The types of kidney disease that occur among patients with multiple myeloma can be classified by the primary site of injury:
●Primary (AL, ALH, or rarely AH) amyloidosis
●Monoclonal immunoglobulin deposition disease (light chain deposition disease, heavy chain deposition disease, and light and heavy chain deposition disease) (MIDD)