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Tumor necrosis factor-alpha inhibitors: Risk of malignancy

Kimme Hyrich, MD, PhD, FRCPC
Section Editor
Daniel E Furst, MD
Deputy Editor
Paul L Romain, MD


Inhibitors of tumor necrosis factor (TNF)-alpha represent important treatment advances for a number of inflammatory conditions, including rheumatoid arthritis (RA), the seronegative spondyloarthropathies, inflammatory bowel disease (IBD), and psoriasis. TNF-alpha inhibitors offer a targeted strategy that contrasts with the nonspecific immunosuppressive agents traditionally used to treat most inflammatory diseases.

However, multiple potential adverse effects of TNF-alpha inhibition have been reported through both clinical trials and postmarketing surveillance. These include:


Injection site reactions

Infusion reactions


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Literature review current through: Sep 2016. | This topic last updated: Jan 23, 2016.
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