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Tumor necrosis factor-alpha inhibitors and mycobacterial infections

Robert S Wallis, MD
Section Editor
C Fordham von Reyn, MD
Deputy Editors
Anna R Thorner, MD
Paul L Romain, MD


Inhibitors of tumor necrosis factor (TNF)-alpha represent important treatment advances in a number of inflammatory conditions, including rheumatoid arthritis, the seronegative spondyloarthropathies, and inflammatory bowel disease. TNF-alpha inhibitors offer a targeted strategy that contrasts with the nonspecific immunosuppressive agents traditionally used to treat most inflammatory diseases.

However, multiple complications and adverse effects of targeted TNF-alpha inhibition have been identified. These include:

Mycobacterial infection, particularly tuberculosis

Other infections (bacterial, viral, and fungal)

Injection site reactions


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Literature review current through: Jan 2017. | This topic last updated: Tue May 26 00:00:00 GMT+00:00 2015.
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