Official reprint from UpToDate®
www.uptodate.com ©2017 UpToDate, Inc. and/or its affiliates. All Rights Reserved.

Medline ® Abstract for Reference 66

of 'Tricyclic antidepressant poisoning'

Therapeutic plasma exchange in amitriptyline intoxication: case report and review of the literature.
Sari I, Turkcuer I, Erurker T, Serinken M, Seyit M, Keskin A
Transfus Apher Sci. 2011;45(2):183. Epub 2011 Aug 26.
Severe amitriptyline poisoning results in cardiac and neurological toxicity and continues to be a leading cause of significant morbidity and mortality both in children and adults. We present a case of severe amitriptyline poisoning successfully treated with plasma exchange. Due to high plasma protein binding property of amitriptyline, plasma exchange therapy should be considered in cases of severe amitriptyline intoxication as a life saving therapeutic modality.
Pamukkale University, Faculty of Medicine, Department of Hematology, Therapeutic Apheresis Unit, Denizli, Turkey. hisari@gmail.com