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Medline ® Abstract for Reference 5

of 'Tricyclic antidepressant poisoning'

5
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Tricyclic antidepressants. Prolonged plasma levels after overdose.
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Spiker DG, Biggs JT
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JAMA. 1976;236(15):1711.
 
Twenty-four patients hospitalized for overdose of a tricyclic antidepressant were monitored clinically, and serial plasma-drug measurements were taken for up to 144 hours. Six of 24 patients had maximum antidepressant plasma levels greater than or equal to 1,000 ng/ml, and their plasma levels at 96 hours ranged from 170 to 1,280 ng/ml. Patients ingesting substantial tricyclic overdoses may remain medically unstable for days. When high tricyclic levels persist, accurate psychiatric assessment is often impossible.
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PMID