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Treatment, prognosis, and prophylaxis of secondary central nervous system lymphoma

Andrew D Norden, MD
Ephraim Hochberg, MD
Fred H Hochberg, MD
Section Editors
Arnold S Freedman, MD
Patrick Y Wen, MD
Deputy Editor
April F Eichler, MD, MPH


Systemic non-Hodgkin lymphoma (NHL) can involve the nervous system at every level, including peripheral nerve, spinal nerve roots, spinal cord, meninges, and brain; of these, leptomeningeal disease and brain involvement are most common. While central nervous system (CNS) disease must be managed to prevent neurologic morbidity and preserve quality of life, the survival of patients with secondary CNS lymphoma depends upon control of both CNS and systemic disease sites [1,2]. Thus, an effective treatment for secondary CNS lymphoma must address both compartments.

Treatment options for patients with secondary CNS lymphoma include:

High-dose intravenous (IV) chemotherapy

Intrathecal (IT) chemotherapy

Radiation therapy to sites of radiographically apparent symptomatic disease


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Literature review current through: Sep 2016. | This topic last updated: Sep 14, 2016.
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