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Treatment, prognosis, and prevention of Listeria monocytogenes infection

Michael S Gelfand, MD
Section Editors
Daniel J Sexton, MD
Morven S Edwards, MD
Deputy Editor
Anna R Thorner, MD


Listeria monocytogenes is an important bacterial pathogen in neonates, immunosuppressed patients, older adults, pregnant women, and, occasionally, previously healthy individuals. The importance of underlying diseases was illustrated in a series of 165 adults with culture-proven Listeria infection: 69 percent of cases in nonpregnant adults occurred in patients with cancer, AIDS, organ transplant recipients, or corticosteroid therapy [1].

The treatment and prognosis of listerial infection will be reviewed here. The epidemiology, pathogenesis, clinical manifestations, and diagnosis of listerial infection are discussed separately. (See "Epidemiology and pathogenesis of Listeria monocytogenes infection" and "Clinical manifestations and diagnosis of Listeria monocytogenes infection".)


Treatment varies with the different clinical syndromes of listerial infection:

Febrile gastroenteritis

Infection in pregnancy


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Literature review current through: Sep 2016. | This topic last updated: Jul 27, 2016.
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  1. Schuchat A, Deaver KA, Wenger JD, et al. Role of foods in sporadic listeriosis. I. Case-control study of dietary risk factors. The Listeria Study Group. JAMA 1992; 267:2041.
  2. Koopmans MM, Brouwer MC, Bijlsma MW, et al. Listeria monocytogenes sequence type 6 and increased rate of unfavorable outcome in meningitis: epidemiologic cohort study. Clin Infect Dis 2013; 57:247.
  3. Lorber B. Listeriosis. Clin Infect Dis 1997; 24:1.
  4. Lorber B. Listeria monocytogenes. In: Principles and Practice of Infectious Diseases, 7th ed, Mandell GL, Bennett JE, Dolin R (Eds), Churchill Livingstone, Philadelphia 2010. p.2707.
  5. Charpentier E, Gerbaud G, Jacquet C, et al. Incidence of antibiotic resistance in Listeria species. J Infect Dis 1995; 172:277.
  6. Bortolussi R, Mailman TL. Listeriosis. In: Infectious Diseases of the Fetus and Newborn Infant, 7th, Remington JS, Klein JO, Wilson CB, et al (Eds), Elsevier Saunders, Philadelphia 2011. p.470.
  7. Mylonakis E, Hohmann EL, Calderwood SB. Central nervous system infection with Listeria monocytogenes. 33 years' experience at a general hospital and review of 776 episodes from the literature. Medicine (Baltimore) 1998; 77:313.
  8. Hof H, Nichterlein T, Kretschmar M. Management of listeriosis. Clin Microbiol Rev 1997; 10:345.
  9. Drevets DA, Canono BP, Leenen PJ, Campbell PA. Gentamicin kills intracellular Listeria monocytogenes. Infect Immun 1994; 62:2222.
  10. Winslow DL, Pankey GA. In vitro activities of trimethoprim and sulfamethoxazole against Listeria monocytogenes. Antimicrob Agents Chemother 1982; 22:51.
  11. Spitzer PG, Hammer SM, Karchmer AW. Treatment of Listeria monocytogenes infection with trimethoprim-sulfamethoxazole: case report and review of the literature. Rev Infect Dis 1986; 8:427.
  12. Günther G, Philipson A. Oral trimethoprim as follow-up treatment of meningitis caused by Listeria monocytogenes. Rev Infect Dis 1988; 10:53.
  13. Merle-Melet M, Dossou-Gbete L, Maurer P, et al. Is amoxicillin-cotrimoxazole the most appropriate antibiotic regimen for listeria meningoencephalitis? Review of 22 cases and the literature. J Infect 1996; 33:79.
  14. Fernández Guerrero ML, Torres R, Mancebo B, et al. Antimicrobial treatment of invasive non-perinatal human listeriosis and the impact of the underlying disease on prognosis. Clin Microbiol Infect 2012; 18:690.
  15. Grant MH, Ravreby H, Lorber B. Cure of Listeria monocytogenes meningitis after early transition to oral therapy. Antimicrob Agents Chemother 2010; 54:2276.
  16. Manfredi R, Sabbatani S, Marinacci G, et al. Listeria monocytogenes meningitis and multiple brain abscesses in an immunocompetent host. Favorable response to combination linezolid-meropenem treatment. J Chemother 2006; 18:331.
  17. Stepanović S, Lazarević G, Jesić M, Kos R. Meropenem therapy failure in Listeria monocytogenes infection. Eur J Clin Microbiol Infect Dis 2004; 23:484.
  18. Thønnings S, Knudsen JD, Schønheyder HC, et al. Antibiotic treatment and mortality in patients with Listeria monocytogenes meningitis or bacteraemia. Clin Microbiol Infect 2016; 22:725.
  19. Morosi S, Francisci D, Baldelli F. A case of rhombencephalitis caused by Listeria monocytogenes successfully treated with linezolid. J Infect 2006; 52:e73.
  20. Cherubin CE, Appleman MD, Heseltine PN, et al. Epidemiological spectrum and current treatment of listeriosis. Rev Infect Dis 1991; 13:1108.
  21. Salimnia H, Patel D, Lephart PR, et al. Listeria grayi: vancomycin-resistant, gram-positive rod causing bacteremia in a stem cell transplant recipient. Transpl Infect Dis 2010; 12:526.
  22. Poyart-Salmeron C, Carlier C, Trieu-Cuot P, et al. Transferable plasmid-mediated antibiotic resistance in Listeria monocytogenes. Lancet 1990; 335:1422.
  23. Stamm AM. Chloramphenicol: ineffective for treatment of Listeria meningitis. Am J Med 1982; 72:830.
  24. Chang J, Powles R, Mehta J, et al. Listeriosis in bone marrow transplant recipients: incidence, clinical features, and treatment. Clin Infect Dis 1995; 21:1289.
  25. Ooi ST, Lorber B. Gastroenteritis due to Listeria monocytogenes. Clin Infect Dis 2005; 40:1327.
  26. Büla CJ, Bille J, Glauser MP. An epidemic of food-borne listeriosis in western Switzerland: description of 57 cases involving adults. Clin Infect Dis 1995; 20:66.
  27. Linnan MJ, Mascola L, Lou XD, et al. Epidemic listeriosis associated with Mexican-style cheese. N Engl J Med 1988; 319:823.
  28. Olsen SJ, Patrick M, Hunter SB, et al. Multistate outbreak of Listeria monocytogenes infection linked to delicatessen turkey meat. Clin Infect Dis 2005; 40:962.
  29. Gottlieb SL, Newbern EC, Griffin PM, et al. Multistate outbreak of Listeriosis linked to turkey deli meat and subsequent changes in US regulatory policy. Clin Infect Dis 2006; 42:29.
  30. MacDonald PD, Whitwam RE, Boggs JD, et al. Outbreak of listeriosis among Mexican immigrants as a result of consumption of illicitly produced Mexican-style cheese. Clin Infect Dis 2005; 40:677.
  31. Management of Pregnant Women With Presumptive Exposure to Listeria monocytogenes. Obstet Gynecol 2014.
  32. Charlier C, Leclercq A, Cazenave B, et al. Listeria monocytogenes-associated joint and bone infections: a study of 43 consecutive cases. Clin Infect Dis 2012; 54:240.
  33. Armstrong RW, Fung PC. Brainstem encephalitis (rhombencephalitis) due to Listeria monocytogenes: case report and review. Clin Infect Dis 1993; 16:689.
  34. Durack DT, Spanos A. End-of-treatment spinal tap in bacterial meningitis. Is it worthwhile? JAMA 1982; 248:75.
  35. Watson GW, Fuller TJ, Elms J, Kluge RM. Listeria cerebritis: relapse of infection in renal transplant patients. Arch Intern Med 1978; 138:83.
  36. Varma JK, Samuel MC, Marcus R, et al. Listeria monocytogenes infection from foods prepared in a commercial establishment: a case-control study of potential sources of sporadic illness in the United States. Clin Infect Dis 2007; 44:521.
  37. Food Safety and Inspection Service. Control of Listeria monocytogenes in ready-to-eat meat and poultry products; final rule. Fed Regist 2003; 68:34208.
  38. Centers for Disease Control and Prevention (CDC). Preliminary FoodNet data on the incidence of infection with pathogens transmitted commonly through food--10 states, 2007. MMWR Morb Mortal Wkly Rep 2008; 57:366.
  39. Farber JM, D'Aoust JY, Diotte M, et al. Survival of Listeria spp. on raw whole chickens cooked in microwave ovens. J Food Prot 1998; 61:1465.
  40. Centers for Disease Control and Prevention (CDC). Vital signs: Listeria illnesses, deaths, and outbreaks--United States, 2009-2011. MMWR Morb Mortal Wkly Rep 2013; 62:448.
  41. Scallan E, Hoekstra RM, Angulo FJ, et al. Foodborne illness acquired in the United States--major pathogens. Emerg Infect Dis 2011; 17:7.
  42. Bennion JR, Sorvillo F, Wise ME, et al. Decreasing listeriosis mortality in the United States, 1990-2005. Clin Infect Dis 2008; 47:867.
  43. Guevara RE, Mascola L, Sorvillo F. Risk factors for mortality among patients with nonperinatal listeriosis in Los Angeles County, 1992-2004. Clin Infect Dis 2009; 48:1507.
  44. Skogberg K, Syrjänen J, Jahkola M, et al. Clinical presentation and outcome of listeriosis in patients with and without immunosuppressive therapy. Clin Infect Dis 1992; 14:815.
  45. Fernàndez-Sabé N, Cervera C, López-Medrano F, et al. Risk factors, clinical features, and outcomes of listeriosis in solid-organ transplant recipients: a matched case-control study. Clin Infect Dis 2009; 49:1153.
  46. Eckburg PB, Montoya JG, Vosti KL. Brain abscess due to Listeria monocytogenes: five cases and a review of the literature. Medicine (Baltimore) 2001; 80:223.
  47. Roed C, Engsig FN, Omland LH, et al. Long-term mortality in patients diagnosed with Listeria monocytogenes meningitis: a Danish nationwide cohort study. J Infect 2012; 64:34.