Treatment of unfavorable prognosis early (stage I-II) classical Hodgkin lymphoma in adults
- Richard T Hoppe, MD
Richard T Hoppe, MD
- Professor of Radiation Oncology
- Stanford University School of Medicine
- Ann S LaCasce, MD
Ann S LaCasce, MD
- Associate Professor of Medicine
- Harvard Medical School
- Andrea K Ng, MD, MPH
Andrea K Ng, MD, MPH
- Professor, Radiation Oncology, Harvard Medical School
- Brigham and Women's Hospital
- Dana-Farber Cancer Institute
Treatment and prognosis of Hodgkin lymphoma (HL, formerly called Hodgkin's disease) are based on the stage of the disease and certain prognostic features.
Treatment of unfavorable prognosis stage I to II HL in adults will be reviewed here. Overview of treatment of HL, and management of patients with favorable prognosis early stage HL, advanced stage HL, and relapsed/refractory disease are discussed separately.
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- Unfavorable prognosis
- Bulky disease
- COMPONENTS OF TREATMENT
- Chemotherapy regimens
- - ABVD chemotherapy
- - Alternative chemotherapy regimens
- - Number of cycles
- Radiation therapy (RT)
- - Radiation field size
- - Radiation dose
- - Adverse effects
- - Patients at higher risk with RT
- Combined modality therapy
- FUNCTIONAL ASSESSMENT OF RESPONSE BY PET/CT
- Bulky mediastinal disease
- Non-bulky disease
- Special clinical scenarios
- - Patients at higher risk with RT
- - Pregnant women
- - Children and adolescents
- - Older adults
- - Renal impairment
- - HIV-infected patients
- - Infradiaphragmatic disease
- - Nodular lymphocyte-predominant HL
- PATIENT FOLLOW-UP
- CLINICAL TRIALS
- INFORMATION FOR PATIENTS
- SUMMARY AND RECOMMENDATIONS