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Treatment of systemic anaplastic large cell lymphoma

Eric Jacobsen, MD
Section Editor
Arnold S Freedman, MD
Deputy Editor
Alan G Rosmarin, MD


The peripheral T cell lymphomas (PTCL) are a heterogeneous group of generally aggressive neoplasms that constitute less than 15 percent of all non-Hodgkin lymphomas (NHLs) in adults [1]. Anaplastic large cell lymphoma, T/null cell type (ALCL) accounts for approximately 2 percent of adult NHL and is the second or third most common PTCL histology in adults depending on the series analyzed [2,3]. (See "Classification of the hematopoietic neoplasms".)

Four distinct forms of ALCL are recognized based on clinical features and molecular characterization:

Primary systemic ALCL, anaplastic lymphoma kinase positive (ALK-positive ALCL)

Primary systemic ALCL, anaplastic lymphoma kinase negative (ALK-negative ALCL)

Breast implant associated ALCL (iALCL)


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Literature review current through: Sep 2016. | This topic last updated: Sep 28, 2016.
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