Medline ® Abstract for Reference 56
of 'Treatment of restless legs syndrome/Willis-Ekbom disease and periodic limb movement disorder in adults'
56
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Clonazepam and vibration in restless legs syndrome.
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Montagna P, Sassoli de Bianchi L, Zucconi M, Cirignotta F, Lugaresi E
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Acta Neurol Scand. 1984;69(6):428.
There have been no controlled therapeutic trials in Restless Legs Syndrome (RLS). In 6 patients with RLS, a randomized double-blind cross-over trial vs placebo showed a significant efficacy of clonazepam in improving subjective quality of sleep and leg dysaesthesia. Vibratory stimulation of the leg showed a less pronounced and non-significant effect. Clonazepam is a safe and effective drug for treatment of RLS; however its long-term efficacy needs confirmation.
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PMID