Medline ® Abstract for Reference 46
of 'Treatment of restless legs syndrome/Willis-Ekbom disease and periodic limb movement disorder in adults'
46
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Treatment of idiopathic restless legs syndrome (RLS) with gabapentin.
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Happe S, Klösch G, Saletu B, Zeitlhofer J
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Neurology. 2001;57(9):1717.
Nine patients with idiopathic restless legs syndrome (RLS) were treated with 300 mg of gabapentin as an initial dose and an up-titration until relief of symptoms for 4 weeks. Subjective symptoms improved significantly. Polysomnographic data showed a reduction of periodic leg movements during sleep (PLMS) (p = 0.003) and PLMS index (p = 0.001). The authors conclude that gabapentin provides a well-tolerated and effective treatment of idiopathic RLS.
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Department of Clinical Neurology, University of Vienna, Austria. happes@uni-muenster.de
PMID