It is difficult to predict the clinical course of relapsing polychondritis (RPC) because there is a marked inter-patient variability (see "Clinical manifestations of relapsing polychondritis") The patterns that may be seen include:
●Episodic disease activity.
●Smoldering disease with ever-changing severity.
●A fulminant downhill course resulting in death.
●A relatively benign course that is free of clinically evident visceral involvement and is easily managed. It is not possible to estimate the prevalence of this self-limited pattern, since it is likely that many of these cases are not diagnosed.