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Medline ® Abstract for Reference 154

of 'Treatment of relapsed or refractory multiple myeloma'

154
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Effective treatment of advanced multiple myeloma refractory to alkylating agents.
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Barlogie B, Smith L, Alexanian R
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N Engl J Med. 1984;310(21):1353.
 
Twenty-nine patients with advanced refractory multiple myeloma were treated with intermittent high-dose dexamethasone in combination with four-day infusions of vincristine and doxorubicin. Rapid and marked tumor-mass reduction (greater than 75 per cent) was noted in 14 of 20 patients whose disease was resistant to alkylating agents and in 3 of 9 patients with additional resistance to doxorubicin--a result far superior to those in previous trials with similar patients. In responsive patients, remissions were of excellent quality, and survival was significantly longer than in unresponsive patients.
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PMID