Medline ® Abstract for Reference 154
of 'Treatment of relapsed or refractory multiple myeloma'
Effective treatment of advanced multiple myeloma refractory to alkylating agents.
Barlogie B, Smith L, Alexanian R
N Engl J Med. 1984;310(21):1353.
Twenty-nine patients with advanced refractory multiple myeloma were treated with intermittent high-dose dexamethasone in combination with four-day infusions of vincristine and doxorubicin. Rapid and marked tumor-mass reduction (greater than 75 per cent) was noted in 14 of 20 patients whose disease was resistant to alkylating agents and in 3 of 9 patients with additional resistance to doxorubicin--a result far superior to those in previous trials with similar patients. In responsive patients, remissions were of excellent quality, and survival was significantly longer than in unresponsive patients.