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Medline ® Abstract for Reference 141

of 'Treatment of relapsed or refractory chronic lymphocytic leukemia'

141
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The efficacy of alemtuzumab for refractory chronic lymphocytic leukemia in relation to cytogenetic abnormalities of p53.
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Osuji NC, Del Giudice I, Matutes E, Wotherspoon AC, Dearden C, Catovsky D
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Haematologica. 2005;90(10):1435.
 
We reviewed the efficacy of alemtuzumab in the treatment of 28 patients with refractory chronic lymphocytic leukemia (CLL) in whom p53 status was known. Overall responses of 53.6% (complete responses 17.9%) were attained with no significant difference between patients with (50%) or without (55%) p53 deletion (p=0.214). We confirm the efficacy of alemtuzumab in refractory CLL irrespective of p53 deletions, and advocate its introduction earlier in disease course.
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PMID