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Medline ® Abstract for Reference 35

of 'Treatment of refractory edema in adults'

35
TI
High dosage metolazone in chronic renal failure.
AU
Dargie HJ, Allison ME, Kennedy AC, Gray MJ
SO
Br Med J. 1972;4(5834):196.
 
Metolazone is a modified quinazolinesulphonamide and in a dose of between 4 and 7.5 mg is an effective diuretic in man with normal renal function. Fourteen patients with non-oedematous stable chronic renal failure (creatinine clearance ranging from 1.2 to 12 ml/min) were given metolazone in doses ranging from 20-150 mg. A noticeable increase in urine flow and sodium excretion occurred, free water clearance increased, and there was a small but significant increase in potassium excretion. No side effects were noted.
AD
PMID