Medline ® Abstract for Reference 35
of 'Treatment of refractory edema in adults'
High dosage metolazone in chronic renal failure.
Dargie HJ, Allison ME, Kennedy AC, Gray MJ
Br Med J. 1972;4(5834):196.
Metolazone is a modified quinazolinesulphonamide and in a dose of between 4 and 7.5 mg is an effective diuretic in man with normal renal function. Fourteen patients with non-oedematous stable chronic renal failure (creatinine clearance ranging from 1.2 to 12 ml/min) were given metolazone in doses ranging from 20-150 mg. A noticeable increase in urine flow and sodium excretion occurred, free water clearance increased, and there was a small but significant increase in potassium excretion. No side effects were noted.