Adenocarcinomas of the endometrium are the most common gynecologic malignancy in developed countries and the second most common in developing countries (cervical cancer is the most common gynecologic malignancy in developing countries). Among the different histologic types of adenocarcinomas, endometrioid uterine cancers have a more favorable prognosis and typically present at an early stage. Other histologic types of uterine adenocarcinoma (eg, serous, clear cell) are associated with a poorer prognosis.
This topic will review the approach and treatment options for women with recurrent or metastatic endometrial cancer. The initial treatment of low-risk, intermediate-risk, and high-risk endometrial cancers (which includes women who present with locally advanced disease) are covered separately. In addition, chemotherapy protocols used in the treatment of endometrial cancer is available separately.
●(See "Approach to adjuvant treatment of endometrial cancer".)
●(See "Treatment of low-risk endometrial cancer".)
●(See "Adjuvant treatment of intermediate-risk endometrial cancer".)