When autonomic reflexes are impaired or intravascular volume is markedly depleted, a significant reduction in blood pressure occurs upon standing (ie, orthostatic hypotension). Orthostatic hypotension can cause dizziness, syncope, and even angina or stroke.
Symptomatic falls in blood pressure after standing or eating are a frequent clinical problem. The prevalence of orthostatic hypotension varies from 5 to 20 percent in different reports. Many disorders can cause orthostatic hypotension, which can also be a symptom of acute or chronic volume depletion. A related problem, postprandial hypotension (a fall in blood pressure occurring 15 to 90 minutes after meals) is also common in older subjects. Orthostatic hypotension can be a disabling condition and is also a risk factor for cardiovascular and all-cause mortality, as well as falls with attendant morbidity.
This topic will review the treatment of chronic orthostatic and postprandial hypotension. The patient with acute orthostatic hypotension due to volume depletion should be treated with volume replacement.
The causes and evaluation of orthostatic hypotension are discussed separately. POTS is also discussed separately (See "Mechanisms, causes, and evaluation of orthostatic hypotension" and "Postural tachycardia syndrome".)
The following sections on therapy are directed toward the patient with chronic orthostatic hypotension due to autonomic dysfunction. The patient with acute orthostatic hypotension due to volume depletion should be treated with volume replacement.