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Treatment of moderate persistent asthma in adolescents and adults

Stephen Peters, MD, PhD, FACP, FCCP, FAAAAI, FCPP
Jennifer W McCallister, MD, FACP, FCCP
Rodolfo Pascual, MD
Section Editor
Bruce S Bochner, MD
Deputy Editor
Helen Hollingsworth, MD


The principal goals of treatment of moderate persistent asthma are to minimize symptoms, normalize pulmonary function, prevent exacerbations, and improve health-related quality of life. A theoretical goal is to prevent the putative long-term consequences of airway inflammation, particularly airway remodeling and chronic persistent airway obstruction. (See "Pathogenesis of asthma".)

The standard pharmacologic approaches to moderate persistent asthma in adolescents (children over the age of 12 years) and adults will be reviewed here. This information is consistent with the “National Asthma Education and Prevention Program (NAEPP): Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma – Full Report 2007" [1]. Similar guidelines have been published by the Global Initiative for Asthma (GINA) [2].

An overview of asthma management, including trigger control and the use of controller medications for asthma in children younger than 12 years of age, is presented separately. (See "An overview of asthma management" and "Trigger control to enhance asthma management" and "Asthma in children younger than 12 years: Treatment of persistent asthma with controller medications".)


The Expert Panel Report 3 of the National Asthma Education and Prevention Program (NAEPP) describes moderate persistent asthma as being characterized by any of the following (table 1) [1]:

Daily symptoms of asthma


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Literature review current through: Sep 2016. | This topic last updated: Oct 19, 2016.
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