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Medline ® Abstract for Reference 88

of 'Treatment of male sexual dysfunction'

Prevalence and associations of erectile dysfunction in a sample of Italian males with type 2 diabetes.
Derosa G, Romano D, Tinelli C, D'Angelo A, Maffioli P
Diabetes Res Clin Pract. 2015;108(2):329. Epub 2015 Feb 7.
AIM: The aim of this study was to evaluate the prevalence of erectile dysfunction (ED) in a sample of type 2 diabetic patients. As secondary endpoint, we evaluated the levels of some adipocytokines in patients with and without ED.
MATERIAL AND METHODS: We enrolled 220 males affected by type 2 diabetes mellitus. We administered the IIEF (International Index of Erectile Function), SAS (self-rating anxiety scale) and SDS (self-rating depression scale) questionnaires. We evaluated body mass index, glycemic control, fasting plasma insulin (FPI), homeostasis model assessment of insulin resistance index (HOMA-IR), lipid profile, sexual hormones, adiponectin (ADN), resistin, retinol binding protein-4 (RBP-4), visfatin, vaspin.
RESULTS: 52.9% of patients were affected by ED. Patients with a HbA1c<7% (53 mmol/mol) in all measurements in the two previous years had a lower incidence of ED, while the prevalence of ED increased with the increasing of times HbA1c was>7% (53 mmol/mol). Patients with ED had higher levels of triglycerides, and higher levels of FPI, 9.9μU/ml vs 8.2μU/ml (p<0.05). Resistin levels were higher in patients with ED compared to those without ED (p<0.05) and free testosterone was lower in patients affected by ED.
CONCLUSIONS: Almost half of type 2 diabetic patients attending our clinic were affected by ED and glycemic control seems to play a role in ED pathogenesis.
Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy; Center for the Study of Endocrine-Metabolic Pathophysiology and Clinical Research, University of Pavia, Pavia, Italy. Electronic address: giuseppe.derosa@unipv.it.