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Medline ® Abstract for Reference 23

of 'Treatment of locoregionally advanced (stage III and IV) head and neck cancer: The oral cavity'

Retromolar trigone squamous cell carcinoma treated with radiotherapy alone or combined with surgery.
Mendenhall WM, Morris CG, Amdur RJ, Werning JW, Villaret DB
Cancer. 2005;103(11):2320.
BACKGROUND: Treatment outcomes were analyzed for retromolar trigone squamous cell carcinoma.
METHODS: Between June 1966 and August 2003, 99 patients were treated with radiotherapy alone (35 patients) or radiotherapy combined with surgery (64 patients). Followup ranged from 0.2 to 23.8 years (median, 3.3 yrs). All living patients had followup for at least 1 year.
RESULTS: The 5-year local-regional control rates after definitive radiotherapy versus surgery and radiotherapy were as follows: Stages I-III, 51% and 87%; Stage IV, 42% and 62%; and overall, 48% and 71%, respectively. The 5-year cause-specific survival rates after definitive radiotherapy compared with surgery and radiotherapy were as follows: Stages I-III, 56% and 83%; Stage IV, 50% and 61%; and overall, 52% and 69%, respectively. Multivariate analyses revealed that the likelihood of cure was better with surgery and radiotherapy compared with definitive radiotherapy.
CONCLUSIONS: The likelihood of cure after treatment for retromolar trigone squamous cell carcinoma was influenced by the extent of disease and treatment. Patients treated with surgery and radiotherapy had a better outcome than those treated with radiotherapy alone.
Departments of Radiation Oncology, University of Florida College of Medicine, Gainesville, Florida 32610, USA. mendewil@shands.ufl.edu