Treatment of locoregionally advanced (stage III and IV) head and neck cancer: The oral cavity
- Nancy Y Lee, MD
Nancy Y Lee, MD
- Attending Physician
- Memorial Sloan-Kettering Cancer Center
- Neil D Gross, MD, FACS
Neil D Gross, MD, FACS
- Associate Professor
- Director of Clinical Research
- Head and Neck Surgery
- MD Anderson Cancer Center
- Scott Okuno, MD
Scott Okuno, MD
- Professor of Oncology
- Division of Medical Oncology
- Mayo Clinic
- Shyam SD Rao, MD, PhD
Shyam SD Rao, MD, PhD
- Assistant Professor of Radiation Oncology
- University of California Davis Comprehensive Cancer Center
- Section Editors
- Bruce E Brockstein, MD
Bruce E Brockstein, MD
- Section Editor — Cancer of the Head and Neck
- Clinical Professor of Medicine
- University of Chicago Pritzker School of Medicine
- David M Brizel, MD
David M Brizel, MD
- Section Editor — Radiation Therapy
- Leonard R Prosnitz Professor of Radiation Oncology
- Professor of Otolaryngology Head & Neck Surgery
- Duke University Cancer Institute
- Marshall R Posner, MD
Marshall R Posner, MD
- Section Editor — Cancer of the Head and Neck
- Professor of Gene and Cell Medicine
- The Tisch Cancer Institute
- Icahn School of Medicine at Mount Sinai
The treatment of locoregionally advanced (stage III and IV (table 1)) squamous cell carcinoma of the oral cavity is discussed here.
An overview of the approach to oral cavity cancer and the treatment of early stage disease are presented separately, as is the management of patients with metastatic and recurrent disease:
ANATOMY AND STAGING
The oral cavity extends from the skin-vermilion junction of the lips to the junction of the hard and soft palate above and to the line of circumvallate papilla of the tongue below (figure 1). The anterior tonsillar pillars and glossotonsillar folds serve as the lateral boundaries between the oral cavity and oropharynx.To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
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- ANATOMY AND STAGING
- General principles
- Pretreatment evaluation
- Treatment of primary tumor
- - Surgical technique
- - Postoperative RT and chemoradiotherapy
- - Induction radiation therapy and/or chemotherapy
- - Nonsurgical candidates
- Oral cavity subsites
- - Lip
- - Floor of mouth
- - Oral tongue
- - Lower alveolar ridge and retromolar trigone
- - Upper alveolar ridge and hard palate
- - Buccal mucosa
- Supportive care measures
- MANAGEMENT OF THE NECK
- POSTTREATMENT EVALUATION AND SURVEILLANCE
- INFORMATION FOR PATIENTS
- SUMMARY AND RECOMMENDATIONS