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Treatment of locoregionally advanced (stage III and IV) head and neck cancer: The oral cavity

Nancy Y Lee, MD
Neil D Gross, MD, FACS
Scott Okuno, MD
Shyam SD Rao, MD, PhD
Section Editors
Bruce E Brockstein, MD
David M Brizel, MD
Marshall R Posner, MD
Deputy Editor
Michael E Ross, MD


The treatment of locoregionally advanced (stage III and IV (table 1)) squamous cell carcinoma of the oral cavity is discussed here.

An overview of the approach to oral cavity cancer and the treatment of early stage disease are presented separately, as is the management of patients with metastatic and recurrent disease:

(See "Treatment of stage I and II (early) head and neck cancer: The oral cavity".)

(See "Treatment of metastatic and recurrent head and neck cancer".)


The oral cavity extends from the skin-vermilion junction of the lips to the junction of the hard and soft palate above and to the line of circumvallate papilla of the tongue below (figure 1). The anterior tonsillar pillars and glossotonsillar folds serve as the lateral boundaries between the oral cavity and oropharynx.

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Literature review current through: Dec 2017. | This topic last updated: Jul 12, 2016.
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