Treatment of locally recurrent squamous cell carcinoma of the head and neck
- Michael T Milano, MD, PhD
Michael T Milano, MD, PhD
- Associate Professor
- Department of Radiation Oncology
- University of Rochester
- Steven J Chmura, MD, PhD
Steven J Chmura, MD, PhD
- Assistant Professor
- University of Chicago
- Daniel J Haraf, MD
Daniel J Haraf, MD
- University of Chicago
- Victoria Banuchi, MD, MPH
Victoria Banuchi, MD, MPH
- Assistant Professor of Otolaryngology
- Weill Cornell Medical College
- Dennis Kraus, MD
Dennis Kraus, MD
- Director, Center for Head and Neck Oncology
- New York Head & Neck Institute
- North Shore-LIJ Health System
- Section Editors
- David M Brizel, MD
David M Brizel, MD
- Section Editor — Radiation Therapy
- Leonard R Prosnitz Professor of Radiation Oncology
- Professor of Otolaryngology Head & Neck Surgery
- Duke University Cancer Institute
- Marvin P Fried, MD, FACS
Marvin P Fried, MD, FACS
- Section Editor — Head and Neck Surgery
- Professor and University Chairman, Department of Otorhinolaryngology - Head and Neck Surgery
- Montefiore Medical Center, Albert Einstein College of Medicine
Recurrent disease is a major cause of morbidity and an obstacle to long-term survival in squamous cell carcinoma of the head and neck. Locoregional recurrences are seen in 15 to 50 percent of patients with squamous cell carcinoma of the head and neck, and this is a major factor contributing to deaths from head and neck cancer [1-3].
Recurrent head and neck cancer is difficult to treat for multiple reasons, including the effects of prior treatment on tumor cells as well as the infiltrative and multifocal nature that typically characterizes recurrent disease in this area .
The approach to treatment for patients with locally recurrent squamous cell carcinoma of the head and neck will be reviewed here. Recurrent nasopharyngeal cancer and recurrent salivary gland tumors are discussed separately.
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- GENERAL PRINCIPLES
- Patient selection
- Treatment options
- SALVAGE SURGERY
- Open surgical salvage
- - Complications
- - Advances in reconstructive surgery
- Conservative approaches
- - Partial laryngectomy
- - Transoral robotic surgery
- - Transoral laser microsurgery
- Prophylactic neck dissection
- Isolated neck recurrence
- Postoperative radiation therapy
- PALLIATIVE CHEMOTHERAPY
- SUMMARY AND RECOMMENDATIONS