Although HIV-1 infection is associated with most of the global AIDS pandemic, HIV-2 is an important cause of disease in certain regions of the world where it is endemic, such as West Africa . Although multiple studies suggest that HIV-2 is generally less pathogenic than HIV-1, mortality rates among HIV-1 and HIV-2 infected patients with advanced disease appear similar when adjusting for CD4 cell count, age, and sex [1-15]. Thus, antiretroviral therapy (ART) plays an important role in patient management.
This topic will address the approach to treatment of the HIV-2 infected patient. The epidemiology, natural history, clinical manifestations, and diagnosis of HIV-2 infection are discussed in detail elsewhere. (See "Epidemiology, transmission, natural history, and pathogenesis of HIV-2 infection" and "Clinical manifestations and diagnosis of HIV-2 infection".)
GOALS OF THERAPY
As with HIV-1 infection, the following benchmarks are critical goals of antiretroviral therapy [16,17]:
●Reduced morbidity and mortality
●Improvement in quality of life