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Treatment of early (stage I and II) head and neck cancer: The hypopharynx

Suisui Song, MD
Joseph K Salama, MD
James W Rocco, MD, PhD, FACS
Section Editors
Bruce E Brockstein, MD
David M Brizel, MD
Marshall R Posner, MD
Marvin P Fried, MD, FACS
Deputy Editor
Michael E Ross, MD


The hypopharynx lies posterior and inferior to the oropharynx and extends to the esophageal inlet. Over 95 percent of hypopharyngeal cancers are squamous cell carcinomas. Other less common histologies include basaloid squamous carcinomas, spindle cell carcinomas, and minor salivary gland carcinomas.

At diagnosis, less than 15 percent of hypopharyngeal cancers are confined to the hypopharynx. Most have spread to the regional lymph nodes (65 percent) or distantly (20 percent). Presenting symptoms can include dysphagia, odynophagia, otalgia, hoarseness, dyspnea/stridor, and/or a painless neck mass. Diagnosis at an early-stage is uncommon due to a lack of alarming symptoms until local progression or neck metastasis is present. Countries that have introduced national diagnostic screening programs for early gastrointestinal (GI) malignancies are more likely to detect hypopharyngeal malignancy at an earlier stage.

The treatment of early hypopharyngeal cancers is presented here. The treatment of locally advanced hypopharyngeal cancer is discussed separately, as is the management of metastatic disease.

(See "Treatment of locoregionally advanced (stage III and IV) head and neck cancer: The larynx and hypopharynx".)

(See "Treatment of metastatic and recurrent head and neck cancer".)


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Literature review current through: Sep 2016. | This topic last updated: Mar 15, 2016.
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