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Medline ® Abstract for Reference 8

of 'Treatment of chronic hepatitis B in the HIV-infected patient'

Hepatitis B in HIV-infected patients.
Soriano V, Poveda E, Vispo E, Barreiro P
Clin Liver Dis. 2013;17(3):489. Epub 2013 Jul 8.
Chronic hepatitis B virus (HBV) infection is common in HIV-positive individuals. Although HBV vaccination is mandatory for HIV-positive individuals with negative-HBV markers, lower rates of protection are achieved. HIV infection accelerates the course of liver disease caused by chronic HBV infection, leading to end-stage hepatic illness and increasing the risk of hepatocellular carcinoma. Anti-HBV active agents, especially tenofovir, improve outcomes. Lamivudine alone should be limited to patients with low serum HBV-DNA levels, since selection of drug resistance often compromises long-term benefits, leads to cross-resistance with other antivirals, and favors the potential emergence of HBV-vaccine escape mutants.
Department of Infectious Diseases, Hospital Carlos III, calle Sinesio delgado 10, Madrid 28029, Spain. vsoriano@dragonet.es