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Medline ® Abstract for Reference 48

of 'Treatment of chronic hepatitis B in the HIV-infected patient'

Recombinant alpha interferon for chronic hepatitis B in anti-HIV positive patients receiving zidovudine.
Marcellin P, Boyer N, Colin JF, Martinot-Peignoux M, Lefort V, Matheron S, Erlinger S, Benhamou JP
Gut. 1993;34(2 Suppl):S106.
In this pilot study of the effects of interferon alfa in 10 anti-HIV positive, chronic hepatitis B patients treated with zidovudine (AZT), tolerance to interferon was good and similar to that in anti-HIV negative patients. After treatment, the HIV stage and CD4 lymphocyte count were unchanged. In two patients hepatitis B virus (HBV)-DNA and hepatitis B e antigen (HBeAg) disappeared and the serum alanine aminotransferase (ALT) returned to normal; loss of hepatitis B surface antigen (HBsAg) with absence of histopathological activity was observed after treatment in one of these patients. These preliminary results need to be confirmed by a larger study.
Service d'Hépatologie, Hôpital Beaujon, Clichy, France.