Treatment of Candida infection in neonates
- Mohan Pammi, MD, PhD
Mohan Pammi, MD, PhD
- Associate Professor
- Baylor College of Medicine
Candida has emerged as an important cause of neonatal infections with significant morbidity and mortality, especially in extremely low and very low birth weight infants, defined as birth weights below 1000 g and 1500 g, respectively [1-5]. Successful management of neonatal candidiasis requires effective treatment of candidal infection with appropriate antifungal therapy and supportive care, and preventive measures to reduce the risk of systemic candidal infections.
The treatment of Candida infections in neonates will be reviewed here. The clinical manifestations, diagnosis, etiology, risk factors, and prevention of neonatal candidal infections are discussed separately. (See "Clinical manifestations and diagnosis of Candida infection in neonates" and "Epidemiology and risk factors for Candida infection in neonates" and "Prevention of Candida infection in neonates".)
In addition, the treatment of breastfeeding mothers with candidal skin infections is also presented elsewhere. (See "Common problems of breastfeeding and weaning", section on 'Candidal infection'.)
Management of Candida infections is dependent upon the clinical presentation of candidal infection. (See "Clinical manifestations and diagnosis of Candida infection in neonates".)
●Candidemia and invasive focal infection – Treatment consists of systemic antifungal agents and the removal of any potentially contaminated medical hardware, such as a central venous catheter or bladder catheter.
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- Removal of medical hardware or fungal mass
- Overview systemic antifungal therapy
- Amphotericin B
- - Side effects
- - Duration of therapy
- - Amphotericin B lipid formulations
- Our approach to treating candidemia
- Surveillance cultures
- MUCOCUTANEOUS CANDIDIASIS
- SOCIETY GUIDELINE LINKS
- SUMMARY AND RECOMMENDATIONS