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Medline ® Abstract for Reference 42

of 'Treatment of androgenetic alopecia in men'

Meta-analysis of efficacy of platelet-rich plasma therapy for androgenetic alopecia.
Gupta AK, Carviel JL
J Dermatolog Treat. 2017;28(1):55. Epub 2016 May 6.
BACKGROUND: Platelet-rich plasma (PRP) therapy is used as an off-label treatment for androgenetic alopecia (AGA); however, published efficacy evidence is still preliminary.
OBJECTIVE: Conduct a meta-analysis of current trial data to estimate efficacy.
METHODS: Thirteen studies which investigated the use of PRP for treatment of AGA were identified from the literature. A meta-analysis was used to analyze results from four trials (N = 60) where sufficient quantifiable data extraction was possible. All 13 studies were analyzed qualitatively.
RESULTS: When comparing PRP treatment to baseline, the overall standardized mean difference was 0.51 [95% confidence interval (CI): 0.14, 0.88; I(2 )=( )0%]in favour of PRP treatment.
CONCLUSION: Preliminary results suggest that the investigation of PRP for the treatment of AGA is promising. Controlled trials withquantifiable measures of treatment success are now required to confirm these results.
a Department of Medicine , University of Toronto School of Medicine , Toronto , Ontario , Canada.