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Medline ® Abstract for Reference 12

of 'Treatment of acute exacerbations of multiple sclerosis in adults'

Relative efficacy of intravenous methylprednisolone and ACTH in the treatment of acute relapse in MS.
Thompson AJ, Kennard C, Swash M, Summers B, Yuill GM, Shepherd DI, Roche S, Perkin GD, Loizou LA, Ferner R
Neurology. 1989;39(7):969.
To compare the efficacy of high-dose intravenous methylprednisolone with intramuscular ACTH in the treatment of acute relapse in multiple sclerosis, we undertook a double-blind, randomized, controlled study involving 61 patients. There was a marked improvement in both groups in the course of the study, but no difference between them in either the rate of recovery or the final outcome. High-dose IV methylprednisolone is a safe alternative to ACTH in the management of acute relapse in MS.
Department of Neurology, London Hospital, UK.